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Clinical Manifestations of Systemic Lupus Erythematosus (SLE)

#Systemic #Lupus #Erythematosus #SLE #Manifestations #Signs #Symptoms #Rheumatology #Diagnosis
Systemic Lupus Erythematosus ... Systemic #Lupus #Erythematosus ... Manifestations #Signs ... #Symptoms #Rheumatology
Erythematous Rashes - THE ALGORITHMIC APPROACH

Characterized by diffuse redness of the skin due to
capillary congestion, erythematous
Erythematous Rashes ... capillary congestion, erythematous ... the Nikolsky sign ... the Nikolsky sign ... or Nikolsky sign
Skin Conditions Associated with Joint Pain

Rash
	• Human parvovirus B19 infection

Malar rash
	• SLE
	• Human parvovirus B19 infection
	•
• Rheumatic fever ... Vesicopustule on erythematous ... Discoid lupus erythematosus ... differential #diagnosis #rheumatology
Systemic Lupus Erythematosus - Diagnosis
Manifestations:
 - Arthritis 69%
 - Malar rash 40%
 - Fever 36%
 -
Systemic Lupus Erythematosus ... Malar rash 40% - Fever ... Systemic #Lupus #Erythematosus ... autoantibodies #signs ... #differential #rheumatology
Scarlet fever
• Delayed-type skin reactivity to pyrogenic exotoxin Requires prior exposure
• Diffuse erythematous eruption that generally
Scarlet fever • ... exposure • Diffuse erythematous ... folds #Scarlet #fever ... clinical #photo #signs
Clinical Features of Systemic Lupus (SLE)
General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%)
Eye: Sjögrens (15%)
Skin
(SLE) General: Fever ... SLE #systemic #erythematosus ... #signs #symptoms ... #diagnosis #rheumatology
Combination of Skin Findings and Arthritis in Pediatrics Patient - Differential Diagnosis
Malar rash: 
 • A
butterfly-like erythematous ... lighter center and erythematous ... not be seen try focus ... Suggestive of: Rheum Fever ... migrans: • Target sign
Systemic Lupus Erythematosus (SLE) - Typical Signs/Symptoms
Alopecia, Fever, Malar rash, Photosensitivity, Adenopathies, Lupus pneumonia, Pleurisy, Pancreatitis,
Systemic Lupus Erythematosus ... SLE) - Typical Signs ... Symptoms Alopecia, Fever ... #SLE #Signs #Symptoms ... #diagnosis #rheumatology
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Systemic Lupus Erythematosus ... weight loss, and fever ... Non-autoimmune rheumatologic ... to: Arthritis, Fever ... #Diagnosis #Rheumatology
EULAR/ACR Classification Criteria for Systemic Lupus Erythematosus
Clinical Domains:
 • Constitutional domain: Fever
 • Cutaneous domain: Non-scarring
Systemic Lupus Erythematosus ... Constitutional domain: Fever ... Systemic #Lupus #Erythematosus ... #diagnosis #rheumatology