13 results
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines

ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Acute-on-Chronic ... months without treatment ... #Chronic #Liver ... #Hepatology #gastroenterology ... #management #diagnosis
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework
Mild (<100-500): 
 • NAFLD
 • Cirrhosis
 •
• NAFLD • Cirrhosis ... • Chronic Viral ... Hepatopathy • Acute ... Viral Hepatitis ... #hepatology #transaminitis
Patterns of Liver Injury
Transaminase Levels:
  > 50x normal - Ischemic Hepatitis
  > 20x normal
> 20x normal - Acute ... CMV), Alcoholic cirrhosis ... 5-10x normal - Chronic ... Liver #Injury #hepatology ... #differential #diagnosis
Causes of Thrombocytosis - Differential Diagnosis Algorithm
Spurious:
 • Artifact (redo CBC)
Autonomous:
 • Essential thrombocytosis
 • Polycythemia
- Differential Diagnosis ... Algorithm Spurious ... Infectious: • Acute ... effect following treatment ... #Hematology
Chronic Hepatitis B - Diagnosis and Management Algorithm

• Who to treat: Essentially treat the pts with
Chronic Hepatitis ... viremia or have cirrhosis ... Chronic Hepatitis ... #Algorithm #Diagnosis ... #Hepatology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm

Peripheral Smear concerning for malignancy?
- Differential Diagnosis ... → Refer to hematology ... Rebound effect from treatment ... • Infections: Chronic ... #Algorithm #hematology
Causes of Diffuse Lymphadenopathy - Differential Diagnosis Algorithm
Reactive:
 - Systemic Inflammatory
     •
Algorithm Reactive ... Tuberculosis • Hepatitis ... Fatigue • Acute ... Age > 50 • Chronic ... #Hematology #Oncology
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm
DILI suspicion
Features toxic aetiology: Skin involvement, Kidney injury,
DILI) - Stepwise Diagnosis ... Algorithm DILI ... non-essential drug/HDS treatments ... dechallenge • Acute ... #Algorithm #hepatology
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
- Differential Diagnosis ... Algorithm Vascular ... > 2 • NASH, Chronic ... : < 1 • Cirrhosis ... #algorithm #hepatology
Autoimmune Hepatitis

Clinical Presentation
 - Highly variable clinical presentation, from subclinical disease to acute liver failure.
 -
Autoimmune Hepatitis ... subclinical disease to acute ... - Symptoms of chronic ... regarding need for treatment ... #Management #Hepatology