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management dermatology adultonset blood dermatomyositis differential product reactions syndrome activation adult antimda5 antimda5dm antinxp2 antinxp2dm atopic atopy autoimmune causes ckd
Adult-Onset Still's Disease (AOSD) Rare inflammatory disorder of unknown etiology, difficult to diagnose because of heterogenous presentation.
Adult-Onset Still's ... Disease (AOSD) ... maculopapular rash ... #Disease #AOSD ... #rheumatology #diagnosis
Adult-Onset Still's Disease Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia + Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
Adult-Onset Still's ... Arthralgia/arthritis, Skin ... rash ± odynophagia ... #Disease #diagnosis ... #rheumatology
Adult Onset Still's Disease Systemic inflammation with urticarial rash. Rash: • Nonpruritic, evanescent (correlates with time of
Adult Onset Still's ... maculopapular skin ... #Stills #disease ... #AOSD #diagnosis ... #rheumatology #
Adult Onset Still's Disease - Yamaguchi Criteria Major criteria: - Fever >= 39C lasting >= 1 weeks
Adult Onset Still's ... weeks - Typical skin ... rash: maculopapular ... #Criteria #Diagnosis ... #Major #Minor #Rheumatology
Cold Urticaria Prevalence - 0.05% in the population Disease onset - Mostly 2nd to 4th decades of life Causes
onset - Mostly ... Insect stings Disease ... , liquids The onset ... Cold #Urticaria #diagnosis ... #rheumatology #
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
sJIA) • Adult-onset ... Still disease ... erythematosus [SLE], AOSD ... #Management #Hematology ... #Rheumatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
3rd Decade Skin ... Differential Diagnosis ... arthritis, adult-onset ... Still disease, ... #Rheumatology
Sweet Syndrome Acute febrile neutrophilic dermatosis (Sweets Syndrome) is a skin condition characterized by fever and inflamed
with systemic disease ... Fever + sudden onset ... of a rash - Rash ... , breast CA - Hematologic ... Treatment: - Systemic
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
• Autoimmune diseases ... SLE+++, Adult-onset ... Still disease, ... #management #treatment ... #summary #rheumatology
ANTI-MDA5 DERMATOMYOSITIS Cutaneous manifestations: • Periorbital heliotrope (blue-purple) rash with edema • Erythematous rash on the face, or the
(blue-purple) rash ... anti-MDA5 DM at onset ... severity of the disease ... Dermatomyositis #rheumatology ... #dermatology #diagnosis
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