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management differential rheumatology druginduced hemolysis dermatology extravascular intravascular oncology sle activation atopic atopy bacilliformis bartonella classification comparison dermatitis dili eczema
Hemolysis - Diagnostic Algorithm and Causes Increased red cell production: • Increased Reticulocytosis/polychromasia • Erythroid
Hemolysis - Diagnostic ... Algorithm and Causes ... #Hemolytic #Anemia ... #Causes #Workup ... #Hematology #Diagnosis
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... Extravascular Causes ... anemia): ... usually IgG) (e.g. lupus ... #hematology #anemia
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
Causes of Extravascular ... - Differential Diagnosis ... anemia • ... #Algorithm #Causes ... #Hematology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... - Differential Diagnosis ... Algorithm • Sickle ... #Diagnosis #Algorithm ... #workup #hematology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
for workup, including ... blood loss, Acute hemolysis ... , deficiency anemia ... Rebound effect from treatment ... #Algorithm #hematology
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
• Immunologic Workup ... constitutional symptoms • Treatment ... • Immunologic Workup ... life-threatening • Treatment ... #diagnosis #management
Pancytopenia - Differential Diagnosis Algorithm • 12-13 g/dL, • ANC < 1800/uL, • platelet < 150,000/uL Initial
Algorithm • 12 ... -13 g/dL, • ANC ... ↑ Destruction (hemolysis ... Matthew Ho, MD ... #Algorithm #hematology
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
(SLE) - Diagnosis ... of SLE versus DIL ... • Immunologic Workup ... Positive in 60-80% of cases ... life-threatening • Treatment
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
) - Stepwise Diagnosis ... Algorithm DILI ... treatments Search ... for alternative causes ... #Algorithm #hepatology
Drug Induced Lupus (DIL) • Epidemiology: -10% of all lupus cases, drug-dependent, 4:1 to 1:1 F:M
• Immunologic Workup ... constitutional symptoms • Treatment ... Discontinuation of causal ... #DIL #rheumatology ... #diagnosis #treatment
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