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differential management rheumatology thrombocytopenia dermatology druginduced oncology purpura activation anesthesia anesthesiology bruising checklist classification comparison crisis disorders erythematosus hemolytic hodgkins
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
Lupus (DIL): ... , SCLE-DIL (terbinafine ... • Immunologic Workup ... • Immunologic Workup ... #diagnosis #management
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
for workup, including ... hemolysis, deficiency anemia ... Rebound effect from treatment ... Glucocorticoids, IL ... #Algorithm #hematology
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
(SLE) - Diagnosis ... versus DIL • ... • Immunologic Workup ... Positive in 60-80% of cases ... life-threatening • Treatment
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
- Differential Diagnosis ... and Workup History ... test, ANA (e.g., SLE ... changes), high MCV anemia ... #Causes #Workup
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
- Differential Diagnosis ... - Hemolytic anemia ... Splenomegaly - CTD (SLE ... Associated - SLE ... #hematology #rheumatology
Causes of Thrombocytopenia - Differential Diagnosis Algorithm Decreased Megakaryopoiesis • Aplastic Anemia • Toxic Damage (e.g.
Megakaryopoiesis • Aplastic Anemia ... Autoimmune • ITP • SLE ... • TTP/HUS • DIC ... #Algorithm #Causes ... #Hematology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... Algorithm • Sickle ... with or without platelet ... #Algorithm #workup ... #hematology #testing
Causes of Purpura or Easy Bruising in Children Platelet count reduced, i.e. thrombocytopenia - Increased platelet destruction
Causes of Purpura ... thrombocytopenia) - SLE ... (systemic lupus ... purpura - DIC ... peds #pediatrics #diagnosis
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
formed or don’t work ... with isolated del ... Workup: • Complete ... Myelodysplastic #Syndromes #diagnosis ... #hematology #oncology
Causes of Petechial Rash - Differential Diagnosis Algorithm Pinpoint areas (less than 2 mm) of hemorrhage, which
Causes of Petechial ... Thrombocytopenia - Abnormal platelet ... Autoimmune Vasculitis (lupus ... deficiency Work ... #Algorithm #Causes
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