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rheumatology differential management erythematosus lupus sle classification oncology vasculitis algorithm monoclonal signs symptoms abnormal activation behcet cancer cerebritis cns criteria
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
, weight loss, abdominal ... develop leukostasis syndrome ... • Tumor lysis syndrome ... #Leukemia #Hematology ... #Oncology #Diagnosis
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Clinical Features ... Demyelinating syndromes ... valve lesions Abdominal ... signs #symptoms #diagnosis ... #rheumatology
Monoclonal Gammopathy of Clinical Significance (MGUS) - Differential Diagnosis Neurologic-Centered: (+) Systemic Features: POEMS, AL amyloid, Cryoglobulinemia
Gammopathy of Clinical ... - Differential Diagnosis ... Features: POEMS, AL ... capillary leak syndrome ... #hematology #oncology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Clinical Presentation ... Fever is the main clinical ... purpura to mucosal bleeding ... #Diagnosis #Management ... #Hematology #Rheumatology
EULAR/ACR Classification Criteria for Systemic Lupus Erythematosus Clinical Domains: • Constitutional domain: Fever • Cutaneous domain: Non-scarring
EULAR/ACR Classification ... Criteria for Systemic ... Erythematosus Clinical ... pericarditis • Hematologic ... Erythematosus #diagnosis
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
Systemic disease ... association • M > F Clinical ... (Clinical Dx). ... • Nonsurgical abdominal ... signs #symptoms #rheumatology
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Manifestations of Systemic ... Erythematosus (SLE) Clinical ... Demyelinating Syndrome ... inflammation, leading ... permeability Diagnosis
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
neuropathy) • Systemic ... Hypergammaglobulinemic macular ... Evans • ITP • Cl-NH ... Paraproteinemias #Hematology ... #Differential #Diagnosis
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
- Differential Diagnosis ... - GI tract: abdominal ... • Cogan Syndrome ... Supply gut -> abdominal ... #rheumatology #
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
activate the immune system ... , leading to the ... : • Clinical triad ... Labs/Diagnosis: ... disorder (e.g. systemic
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