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diagnosis management hematology lupus oncology algorithm differential hemeonc medications sle table apml behcets cancer comparison criticalcare dil disease diuresis diuretics
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation ... Syndrome in APML ... Incidence: common in APL ... Triggers: ATRA treatment ... #Syndrome #APML
Behcet's Syndrome - Treatment Ulcers: • Treatment: Topical steroids • Prevention: Colchicine • Azathioprine for refractory disease Arthritis:
Behcet's Syndrome ... : • Treatment: ... Behcets #disease #Syndrome ... #pharmacology # ... rheumatology
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
thiazidic, PPI, ACE ... constitutional symptoms • Treatment ... life-threatening • Treatment ... Lupusreference #druginduced ... comparison #table #rheumatology
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
have fever - ACS ... organ damage • Treatment ... Low calcium • Treatment ... - Hyperkalemia treatment ... diagnosis #management #hematology
Summary of Oncologic Emergencies Neutropenic fever: - Fever + ANC < 500 → start cefepime ± vancomycin (if
→ no immediate treatment ... oncology early Differentiation ... with AML (~20 % ... ) and APL (~25 % ... : continue differentiating
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
factor (GCSF) treatments ... marrow studies Treatment ... progression to AML ... Immunosuppressive treatment ... #diagnosis #hematology
There are similarities and differences between these 3 conditions which all carry treatment implications. Each mimic
conditions which all ... carry treatment ... limited utility in differentiation ... for Refeeding Syndrome ... algorithm #management #treatment
Diuretics and Agents Regulating Renal Excretion Carbonic Anhydrase Inhibitors (Acetazolamide, Dichlorphenamide) • Glaucoma • Epilepsy • Altitude
disequilibrium syndrome ... Inhibitors of Na+K+2Cl ... and nephrotic syndrome ... Tolvaptan) • Treatment ... Diuresis #Nephrology #Pharmacology
Drug Induced Lupus (DIL) • Epidemiology: -10% of all lupus cases, drug-dependent, 4:1 to 1:1 F:M
thiazidic, PPI, ACE ... constitutional symptoms • Treatment ... Lupusreference #DrugInduced ... #Lupus #DIL #rheumatology ... #diagnosis #treatment
Drug Induced Systemic Lupus Erythematosus > 100 drugs have been associated with drug-induced SLE High risk (>5%): •
for 1 year of treatment ... Lupusreference #DrugInduced ... medications #drugs #pharmacology ... differential #diagnosis #rheumatology
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