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diagnosis differential management antibodies classification dermatology diseases lupus pulmonary table ana antibody antineutrophil antinuclear associations autoantibodies causes comparison cryoglobulins cutaneous
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
syndrome Anti-Scl ... c-ANCA - Vasculitis ... granulomatosis p-ANCA ... - Vasculitis, e.g ... diagnosis #table #rheumatology
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
in drug-induced SLE ... scleroderma) - Anti-Scl ... Vasculitis: • ... Renal-limited vasculitis ... antibodies #diagnosis #rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
+MPO) • Cryoglobulinemic ... Vasculitis: + MPO-ANCA ... Low levels mixed cryoglobulinemia ... , and SLE) • Urinalysis ... differential #diagnosis #rheumatology
Pulmonary Renal Syndromes and Mimics - Differential Diagnosis Framework Diffuse alveolar hemorrhage + rapidly progressive glomerulonephritis 90%: -
glomerulonephritis 90%: - ANCA ... Double Positive (ANCA ... Complement Levels: SLE ... , Cryoglobulinemic ... differentiation syndrome in APL
Vasculitis Involving the Skin - Differential Diagnosis Framework Primary: 50% Cutaneous Vasculitis: Leukocytoclastic Vasculitis Secondary: CTD: SLE, RA
Secondary: CTD: SLE ... Urticarial/LCV) - Cryoglobulinemic ... ANCA Associated: ... : • Behcet Disease ... #dermatology #rheumatology
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• Autoimmune diseases ... : - 10% SLE or ... DDX: • ANCA (Antineutrophil ... erythematosus (SLE ... classification #rheumatology
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Splenomegaly - CTD (SLE ... /HSP • Cryoglobulinemia ... (MIXED) • ANCA ... Associated - SLE ... #rheumatology #
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
, such as SLE, atherosclerotic ... disease, drug reactions ... most important diseases ... + MPO) Cryoglobulinemic ... Differential #Diagnosis #Rheumatology
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
thiazidic, PPI, ACE ... constitutional symptoms • Treatment ... life-threatening • Treatment ... Evolution: Chronic disease ... comparison #table #rheumatology
Hemoptysis - Differential Diagnosis Framework Massive Hemoptysis: >150-300 mL in 24h Airway disease: • Bronchitis, Bronchiectasis, Malignancy
in 24h Airway disease ... / Autoimmune: ANCA-Assoc ... vasculitis (GPA ... > EGPA, MPA), Cryoglobulinemia ... Goodpasture's, SLE
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