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differential ana antibodies antibody antinuclear associations autoantibodies comparison inflammatory management nuclear testing arthritis bone cardiomyopathy causes clinical cytoplasmic disease diseases
Autoantibodies in Rheumatology • Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and
Autoantibodies in Rheumatology ... • Lupus (SLE): ... Autoantibodies #Rheumatology ... #diagnosis #associations ... #table
Antinuclear Antibody Testing - Nuclear and Cytoplasmic Patterns Nuclear Patterns: • Homogeneous pattern: -
: - SLE, SSc ... Smith, Sm/RNP, Scl ... Scl100, Th/To, Scl ... #differential #diagnosis ... #rheumatology
Myositis Specific Antibodies (MSAs) Dermatomyositis: MDA5, TIF1y, NXP2, Mi-2, SAE Anti-Synthetase Syndrome: Jo-1, PL7, PL12, EJ, OJ Immune Mediated
, TIF1y, NXP2, Mi ... -2, SAE Anti-Synthetase ... MSAs #clinical #diagnosis ... #rheumatology # ... table
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
RA Anti-dsDNA - SLE ... - Drug-induced SLE ... syndrome Anti-Scl ... Associations #diseases #diagnosis ... #table #rheumatology
Inflammatory Myopathies Dermatomyositis • Onset: Subacute • Pattern: Proximal • CK: Up to 50X ULN • Autoantibodies:
Anti-MDA5, anti-Mi ... Associated Features: Diagnosis ... #differential #diagnosis ... #comparison #rheumatology ... #table
Antinuclear Antibody Testing - Nuclear Patterns Homogeneous pattern: • SLE, SSc, AIH, JIA • dsDNA, chromatin,
: • SLE, SSc, ... : • SjS, SLE, DM ... Smith, Sm/RNP, Scl ... #differential #diagnosis ... #rheumatology
Causes of Bone/Joint Pain in Sickle Cell Disease Vaso-occlusive pain: • Mechanism: ischemic pain • Can present
predispose to other orthopedic ... • XR, MRI to ... dz difficult to see ... #differential #diagnosis ... #causes #hematology
Arthritis of the Hand - Arthritis Patterns Osteoarthritis: • Osteoarthritis of the hand usually involves the DIP and
Hand - Arthritis Patterns ... ulnar deviation • SLE ... Joint Involvement Patterns ... #hand #diagnosis ... #rheumatology #
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
Epidemiology: -10% of all ... thiazidic, PPI, ACE ... #comparison #table ... #rheumatology # ... diagnosis #management
Peripartum Cardiomyopathy - Summary 1. Definition • Towards the end of pregnancy to 5 months postpartum
Differential Diagnosis ... ancestry, LGE on MRI ... orthopnea, PND, LE ... during Delivery • Stable ... #management #cardiology
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