24 results
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
Differentiation Syndrome ... Incidence: common in APL ... Differentiation #Syndrome ... #management #hematology ... #oncology
Hyperviscosity Syndrome - Causes and Treatment

 - Waldenstrom macroglobulinemia (most common) / Plasmapheresis 
 - Multiple
Hyperviscosity Syndrome ... hyperleukocytosis (AML ... Hyperviscosity #Syndrome ... #Causes #Differential ... #Management
Tumor Lysis Syndrome
An acute, life-threatening condition that appears within 7 days of starting cytotoxic therapies in
Tumor Lysis Syndrome ... and AML) and solid ... #Tumor #Lysis #Syndrome ... #TLS #oncology ... #management #UricAcid
Inherited Defects in Kidney Tubule Epithelial Cells

Renal glucosuria - Na+-dependent glucose cotransporter
Cystinuria - Amino acid transporter
Bartter
transporter Bartter syndrome ... limb Gitelman syndrome ... tubule Liddle syndrome ... deficiency Nephrogenic syndrome ... #Table
Acute Kidney Injury (AKI) in Patients with Cancer 

Cancer Related 
• Hypercalcemia 
• Intravenous contrast 
•
malignancies Treatment ... sinusoidal obstructive syndrome ... Capillary leak syndrome ... • Tumor lysis syndrome ... #Differential #
Myelodysplastic Syndromes (MDS)

What?
Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
Myelodysplastic Syndromes ... transformation to AML ... blood count with differential ... progression to AML ... diagnosis #hematology #oncology
Antiphospholipid Syndrome (APS)
APS is a rare autoimmune disorder characterized by recurring blood clots resulting from antibodies
Antiphospholipid Syndrome ... Antiphospholipid antibodies (aPL ... to be present Treatment ... Antiphospholipid #Syndrome ... APS #diagnosis #management
Monteggia Fracture 
Fracture of proximal ulnar shaft with radial head dislocation. Remember “MUGR” to recall where
), compartment syndrome ... ligamentous injury (LCL ... • If stable ... DC with orthopedic ... #Orthopedics #Proximal
Summary of Oncologic Emergencies

Neutropenic fever:
- Fever + ANC < 500 → start cefepime ± vancomycin (if
TLS (tumor-lysis syndrome ... Hyperviscosity syndrome ... Differentiation syndrome ... : - Seen with AML ... (~20 %) and APL
Rhabdomyolysis - Differential Diagnosis Framework and Management Summary

Causes of Rhabdomyolysis:
 • Trauma:
	- Immobilization
	- Crush injury
	- Compartment
Framework and Management ... - Compartment syndrome ... Neuroleptic malignant syndrome ... or compartment syndrome ... #nephrology