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diagnosis treatment algorithm differential pharmacology hematology neurology cardiology clinical oncology table tls antiphospholipid aps barre checklist guillain lysis tumor ammonia
Tumor lysis syndrome (TLS) - Pathophysiology: → Massive tumor cell lysis → Release of large amounts of K+,
Tumor lysis syndrome ... (TLS) - Pathophysiology ... , AML, NHL → AKI ... #TumorLysis #syndrome ... #TLS #Pathophysiology
Mechanisms of Drug-Induced Hyperkalemia • Direct renin inhibitor (Aliskiren) • Renin release inhibition (NSAIDs, Beta-Blockers)
Angiotensin-converting enzyme (ACE ... • Exogenous (KCL ... Muner Mohamed @MunerMohamed1 ... differential #diagnosis #pathophysiology ... pharmacology #potassium #medications
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... in APML Epidemiology ... Incidence: common in APL ... ATRA treatment Pathophysiology ... #management #hematology
Antiphospholipid Syndrome (APS) APS is a rare autoimmune disorder characterized by recurring blood clots resulting from antibodies
Antiphospholipid Syndrome ... from antibodies formed ... Antiphospholipid antibodies (aPL ... Anticardiolipin antibodies (aCL ... APS #diagnosis #management
Schematic representation of the major sources of ammonia production and its excretory pathway (GI = gastrointestinal,
ileal conduit - Medications ... myeloma, CML, AML ... rare): - Reye syndrome ... deficiency #Ammonia #Pathophysiology
Hyperviscosity Syndrome - Causes and Treatment - Waldenstrom macroglobulinemia (most common) / Plasmapheresis - Multiple
Hyperviscosity Syndrome ... hyperleukocytosis (AML ... Hyperviscosity #Syndrome ... Diagnosis #Treatment #Management
Tumor Lysis Syndrome An acute, life-threatening condition that appears within 7 days of starting cytotoxic therapies in
Tumor Lysis Syndrome ... leukemia (both ALL ... and AML) and solid ... #Tumor #Lysis #Syndrome ... TLS #oncology #management
Management of Serotonin Syndrome Identify and stop all serotoninergic medications • Avoid inadvertent Rx of serotoninergic meds
Management of Serotonin ... Syndrome Identify ... and stop all serotoninergic ... medications • ... #Management #treatment
Shock - Differential Diagnosis Framework - MAP <65. SBP <90, drop in SBP > 40 -
Failure, Toxins/Medications ... Abdominal compartment syndrome ... Differential #Diagnosis #criticalcare ... algorithm #treatment #management
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
vs Tumor Lysis Syndrome ... Leukostasis: • Pathophysiology ... have fever - ACS ... : • Pathophysiology ... TLS #diagnosis #management
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