15 results
Modified Hyponatremia Algorithm
Hypertonic Hyponatremia: Hyperglycemia, Mannitol, Urologic irrigants
Hypotonic Hyponatremia: 
 • ADH ON (UOsm > 100):
ON (UNa < 30): Hypovolemia ... OFF (UNa > 30): SIADH ... , Medications (diuretics ... Hyponatremia #Algorithm #diagnosis ... #sodium #nephrology
Cerebral Salt Wasting vs SIADH - Pathophysiology 
1) Neurological event
2) Sodium loss from tubules
3) Naturiesis →
Cerebral Salt Wasting ... vs SIADH - Pathophysiology ... Neurological event 2) Sodium ... Pathophysiology #diagnosis ... #nephrology #hyponatremia
Hyponatremia Differential Diagnosis Algorithm - Utilizing Uric Acid 
ADH promotes Urea/uric acid excretion along with water
Hyponatremia Differential Diagnosis ... Osmolarity 3) Urine Sodium ... Low Uric Acid → SIADH ... Uric Acid → renal salt ... #Algorithm #nephrology
Management of SIADH
Treat underlying cause:
 • Causes can include pain, primary lung pathology, post-operative phenomenon, medications,
Management of SIADH ... post-operative phenomenon, medications ... promoting passive sodium ... SatyaPatelMD #SIADH ... #hyponatremia #nephrology
Mechanisms of Drug-Induced Hyperkalemia 
 • Direct renin inhibitor (Aliskiren)
 • Renin release inhibition (NSAIDs, Beta-Blockers)
of Drug-Induced Hyperkalemia ... (Heparin) • Sodium-channel ... • Exogenous (KCL ... #differential #diagnosis ... pharmacology #potassium #medications
Physiologic Approach to Hypotonic Hyponatremia
The next time you have a case of hypotonic hyponatremia, give the
, Renal Sodium loss ... Present (Uosm ≥100): Hypovolemia ... #differential #diagnosis ... #table #sodium ... #nephrology
SIADH Treatment Options
1. Treat underlying cause of SIADH: Pain, Primary lung pathology, Post-operative phenomenon, Medications, Basically
SIADH Treatment ... underlying cause of SIADH ... Post-operative phenomenon, Medications ... promoting passive sodium ... #hyponatremia #nephrology
Drugs associated with hypokalemia and hypomagnesemia

Hypokalemia
- Shift from extracellular fluid to intracellular fluid compartment
  -
associated with hypokalemia ... overdose) - Sodium ... hypomagnesemia #Medications ... #differential #diagnosis ... #nephrology #Causes
Volume Based Approach to Hyponatremia
Hypovolemic, Serum uric acid >4
 • Urine Na <20: Extra-renal losses
 •
losses, Cerebral salt ... uric acid <4 • SIADH ... Hyponatremia #algorithm #diagnosis ... #sodium #low #nephrology
Gitelman Syndrome Pathophysiology
Gitelman Syndrome is a rare autosomal recessive salt-losing tubulopathy with a prevalence of 1-
autosomal recessive salt-losing ... thiazide-sensitive sodium-chloride ... H+ secretion → Hypokalemia ... Pathophysiology #nephrology ... #diagnosis