845 results
Liver Chemistries - Interpretation of LFTs

R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP)
 • R >
phos/ULN ALP) ... Cholestasis • ALP ... disease • If ALP ... both are normal - ALP ... • Elevation of ALP
Liver Function Test (LFTs) Elevation
AST - Cardiac and skeletal muscle, kidney, brain
ALT - More specific for
kidney, brain ALT ... for the liver ALP ... Transaminase, ALP ... / ULN ALT) / (ALP ... / ULN ALP)
Low Alkaline Phosphatase - Hypophosphatasia 

Is Low Alkaline Phosphatase Of Clinical Importance?

ALP enzyme- Discovered in 1923
Low
ALP enzyme- Discovered ... in 1923 Low ALP ... 1948 by Rathbun ALP ... Neuropathy ALP ... , ↓ALP → Low
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm

ALP:
 - Enzymes that catalyze hydrolysis of organic phosphate
Alkaline Phosphatase (ALP ... Diagnosis Algorithm ALP ... - Increased ALP ... Surgical consult ALP ... #Phosphatase #ALP
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
specificity to elevated ALP ... • AST/ALT > ALP ... GGT/5-NT: ↑ - ALP ... disease - If ALP ... hemolysis) • ALP
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis
Hepatocellular Pattern (ALT or AST > ALP):
or AST > ALP): ... • Severe - ALT ... • Moderate - ALT ... Cholestatic Pattern (ALP ... > ALT or AST):
Renal Cell Carcinoma (RCC) - Diagnosis and Management Summary
Clinical features - Classic triad (flank pain, hematuria,
bone pain and ↑ ALP ... Hypercalcemia 4. ↑ AST, ALT ... , and/or ALP 5.
Primary Biliary Cirrhosis - Diagnosis Algorithm
Symptoms: Fatigue, Pruritus, Right upper quadrant discomfort
Signs: Jaundice, Xanthelasmata, Hepatomegaly
Associated history:
Elevated ALP 2.
Algorithm for the Diagnosis of Primary Biliary Cholangitis (PBC). 

US, ultrasound; MRCP, magnetic resonance cholangiopancreatography; ALP,
cholangiopancreatography; ALP
Osteomalacia & Osteoporosis in People with HIV
Osteomalacia:
 - Decreased bone matrix mineralization. In people with HIV
Decr PO4, Incr ALP