14 results
Pathophysiology of Tumor Lysis Syndrome (TLS)
Tumor Cell Lysis
-> Release of DNA
 • Purines -> Hypoxanthine /
Pathophysiology ... of Tumor Lysis Syndrome ... (TLS) Tumor Cell ... • Hyperkalemia ... #TLS #Pathophysiology
Tumor lysis syndrome refers to the constellation of metabolic disturbances that occurs when large numbers of
Tumor lysis syndrome ... hyperuricemia, #hyperkalemia ... hyperphosphatemia, #hypocalcemia ... acutekidneyinjury #Pathophysiology ... #Presentation #TLS
Causes of Hypokalemia - Differential Diagnosis Algorithm
Defining the cause of hypokalemia starts by measuring urinary K
Causes of Hypokalemia ... Clinicians should also ... Renin-secreting tumor ... #hypokalemia ... algorithm #causes #nephrology
Hypokalemia Differential Diagnosis Algorithm
Hypertensive:
 • High Al, Low R - Primary aldosteronism
 • High Al, High
Hypokalemia Differential ... Renin-secreting tumor ... acid, Liddle's Syndrome ... #Hypokalemia # ... Diagnosis #Algorithm #nephrology
Adrenal Incidentalomas: Hormone Evaluation
 • Zona Glomerulosa: Primary Hyperaldosteronism?
    - Aldosterone and renin
Aldosterone and renin if hypokalemia ... Fasciculata: Cushing Syndrome ... metanephrines for all ... for those with tumor ... Diagnosis #workup #endocrinology
Anticonvulsants as Mood Stabilizers: Mechanism and Side-effect
Examples: Valproate, Carbamazepine, Lamotrigine
 • Mild anticholinergic effect -> Drowsiness
Anticonvulsants as ... Stevens-Johnson Syndrome ... , asthenia • Neurologic ... #SideEffects #Pathophysiology ... #Psychiatry #Pharmacology
Leukostasis vs Tumor Lysis Syndrome
Leukostasis:
 • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Lysis Syndrome ... Leukostasis: • Pathophysiology ... hyperviscosity syndrome ... • Pathophysiology ... hydration - Hyperkalemia
Hypokalemia Evaluation Algorithm

Before evaluating hypokalemia, life threatening complications such as arrhythmias and paralysis should be looked
Hypokalemia Evaluation ... Before evaluating hypokalemia ... complications such as ... Renin secreting tumor ... differential #potassium #nephrology
Myoedema in Hypothyroidism on Physical Exam

Hypothyroidism is a clinical syndrome resulting from the production, secretion or
is a clinical syndrome ... can occur, such as ... (shown in the video ... PhysicalExam #clinical #video ... #neurology #endocrinology
Causes of Secondary Hypertension - Workup and Differential Diagnosis
Approach (when evaluation should be done):
1. Severe or
heart failure, neurologic ... disorders including hypokalemia ... hormonal excess or hypokalaemia ... Vasculitis • Endocrinologic ... Neurologic disorders