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Approach to Elevated aPTT / PT - Differential Diagnosis Algorithm

aPTT: Intrinsic / Final
PT: Extrinsic / Final

By
Approach to Elevated aPTT ... / PT - Differential ... Intrinsic / Final PT ... #Elevated #aPTT ... #PT #INR #Algorithm
How to Evaluate an Abnormal APTT
Step 1: Is the PT or APTT Artifactually Prolonged?
Step 2: Is
Evaluate an Abnormal APTT ... Step 1: Is the PT ... or APTT Artifactually ... Prolonging the PT ... or APTT?
Algorithm for Investigation of Abnormal Coagulation Tests
- Prolonged PT
- Prolonged aPTT and Prolonged PT
- Prolonged aPTT

Dr.
Tests - Prolonged PT ... - Prolonged aPTT ... and Prolonged PT ... - Prolonged aPTT ... Coagulation #Abnormal #APTT
Causes of Abnormal PT and/or aPTT
Prolonged Prothrombin Time (PT)
1. Acquired deficiency of FVII
Causes of Abnormal PT ... Prothrombin Time (PT ... typically prolong PT ... antibody Prolonged PT ... #Abnormal #PT
Approach to Thrombotic Microangiopathy (TMA) - Differential Diagnosis and Management Algorithm

Suspected TMA: Unexplained thrombocytopenia + MAHA
antiglobulin test, PT ... /aPTT MAHA likely ... hemosiderin • PT ... /aPTT normal •
Markers of Organ Dysfunction in Severe Sepsis 
Altered consciousness 
Confusion 
Psychosis 

Tachycardia 
Hypotension 
Altered CVP 
Altered
Jaundice Enzymes, PT ... Creatinine PT ... /APTT, D-Dimer
Differential Diagnosis for a Prolonged PT and aPTT
If the PT and the aPTT are both prolonged,
for a Prolonged PT ... and aPTT If the ... PT and the aPTT ... #Abnormal #PT ... #aPTT #Prolonged
Effect of Anticoagulants on Coagulation Tests
PT / INR, aPTT, Anti-Xa Activity, Activated Clotting Time, Thrombin Time,
Coagulation Tests PT ... / INR, aPTT, Anti-Xa
Coagulation Cascade Mnemonic - PITT vs PET
PITT (with an I) = Intrinsic = APTT
= Intrinsic = APTT ... E)= Extrinsic=PT
Von Willebrand Disease - Most common inherited bleeding disorder 
Clinical 
 • Easy bruising 
 •
2B) • Normal PT ... INR • Normal aPTT