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differential oncology treatment causes dermatology leukemia symptoms vasculitis blood classification disease eosinophilia hemophagocytic hlh immunology lymphocytic lymphohistiocytosis mds myelodysplastic neurology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
→ Refer to hematology ... Kawasaki, Nephrotic syndrome ... : Chronic infections ... post-splenectomy, Exercise, Allergic ... #Algorithm #hematology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
Malaise, bleeding, infections ... develop leukostasis syndrome ... • Tumor lysis syndrome ... #Leukemia #Hematology ... #Oncology #Diagnosis
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Chronic Lymphocytic ... Leukemia - Summary ... weeks without infection ... Physical Exam/Signs ... workup #oncology #hematology
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Myelodysplastic Syndrome ... Summary myelo ( ... risk-stratification • Risks: infection ... Allogeneic stem cell ... #hematology #oncology
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
- Differential Diagnosis ... Thrombocytosis): • Acute infection ... Myelodysplastic syndrome ... myeloid leukemia (CML ... #Causes #hematology
Basophilia - Differential Diagnosis Framework Basophils < 1% of the total white blood cell count Basophils function similarly
- Differential Diagnosis ... released during an allergic ... Disorders: • Chronic ... #Differential #Diagnosis ... #causes #hematology
Causes of Eosinophilia - Differential Diagnosis Bugs: - Fungus (aspergillosis) - Viral (HIV) - Ectoparasites (scabies, myiasis)
- Differential Diagnosis ... Primary: - CML ... Hypereosinophilic Syndrome ... - Chronic Eosinophilic ... #Causes #hematology
Approach to Elevated Tryptase - Differential Diagnosis Framework The DDx of elevated tryptase can be broken down
- Differential Diagnosis ... • Parasitic infections ... Causes: • Mast cell ... activation syndrome ... #hematology #allergy
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
to impaired B-cell ... Autoimmunity • Chronic ... syndrome, HIV) ... hypogammaglobulinemia #immunology #hematology ... #diagnosis #management
Aplastic Anemia - Illness Script Signs and symptoms: • Recurrent infections from neutropenia • Mucosal bleeding from
Illness Script Signs ... : • Recurrent infections ... Consider stem cell ... #management #treatment ... #hematology
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