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differential hematology management nephrology algorithm anemia hepatitis hodgkins lymphoma mds myelodysplastic syndromes table workup aflp aplastic apml bariatric bee bypass
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Myelodysplastic Syndrome ... marrow) -dys- (abnormal ... only curative treatment ... #Management #treatment ... #hematology #oncology
Hypernatremia Diagnosis and Workup Step 1 . Repeat the sodium concentration. Step 2. Check plasma osmolality. NORMAL PLASMA
Hypernatremia Diagnosis ... NORMAL PLASMA OSMOLALITY ... • renal volume loss ... HYPERVOLEMIC • CHF • liver ... • nephrotic syndrome
Commonly Observed Laboratory Findings in Hepatic / Liver Failure - Elevated conjugated and unconjugated bilirubin -
indicate permanent loss ... anemia; blood loss ... the hepatorenal syndrome ... LiverFailure #Hepatic #Hepatology ... #Laboratory #Diagnosis
Liver Disease in Pregnancy Intrahepatic Cholestasis of Pregnancy (ICP) • Onset/Trimester: 25-32 weeks • Typical clinical features:
Hepatic imaging: Normal ... necrosis HELLP Syndrome ... Disease #Pregnancy #hepatology ... obstetrics #hepatitis #comparison ... #differential #diagnosis
Diagnostic Framework for Anemia (Morphological Approach - MCV) Low MCV - <80fL - "Microcytic" • Iron deficiency
Diagnostic Framework ... some patients) Normal ... disease, Acute blood loss ... : Alcohol use, Liver ... Myelodysplastic syndrome
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
- Differential Diagnosis ... vein: Budd-chiari syndrome ... Injury: • AST: Less ... • Gilbert's syndrome ... #algorithm #hepatology
BEE Syndromes - Non-inflammatory Causes Immune-mediated conditions affecting the Brain, Eye, and Ear Visual or auditory symptoms in
important, as early diagnosis ... and treatment can ... consistent with MS ... #neurology #noninflammatory ... #differential #diagnosis
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Level • AST: Less ... - If both are normal ... • Gilbert's syndrome ... #chemistry #diagnosis ... #differential #Hepatology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... Triggers: ATRA treatment ... Renal Failure Treatment ... 500 mg QD until normal ... #oncology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
(specific loss-of-function ... (MDS) (normal or ... aplastic anemia Treatment ... Aplastic #Anemia #oncology ... #hematology #diagnosis
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