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differential algorithm hematology treatment gastroenterology aih amyloid amyloidosis apml autoimmune bilirubin bleeding bruising causes chemistry congenital criticalcare cvid differentiation dili
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI) DILI Types: • Intrinsic - predictable, dose dependent
Diagnosis and Management ... Idiosyncratic - less common ... Chronic - ongoing ↑ LFTs ... #differential #Diagnosis ... gastroenterology #hepatology
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Elevated Liver Enzymes ... disease US — Normal ... Bile Ducts • Common ... • Others #LFTs ... #Hepatology #LiverEnzymes
Abnormal liver function tests algorithm. This figure details the initial response to abnormal liver blood tests.
Abnormal liver function ... presence of metabolic syndrome ... Areas of diagnostic ... #LFTs #Abnormal ... #Algorithm #Hepatology
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Interpretation of LFTs ... • Gilbert's syndrome ... #chemistry #diagnosis ... #differential #Hepatology ... transaminitis #LFTs
Hypocalcemia - Diagnosis and Management PTH Independent (↑ PTH) • LOW VIT D -
Hypocalcemia - Diagnosis ... and Management ... - Activation: Liver ... (phenytoin) • NORMAL ... Iatrogenic (most common
Commonly Observed Laboratory Findings in Hepatic / Liver Failure - Elevated conjugated and unconjugated bilirubin -
Commonly Observed ... Findings in Hepatic / Liver ... the hepatorenal syndrome ... LiverFailure #Hepatic #Hepatology ... #Laboratory #Diagnosis
Autoimmune Hepatitis Clinical Presentation - Highly variable clinical presentation, from subclinical disease to acute liver failure. -
disease to acute liver ... arthralgias) are common ... upper limit of normal ... Muscle Abs (ASMA) (common ... #Management #Hepatology
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
- Differential Diagnosis ... von Willebrand syndrome ... defects in the common ... #Differential #Diagnosis ... #Hematology
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
disease • Liver ... and M panel Management ... : • Nephrotic syndrome ... (Epstein-Barr syndrome ... #diagnosis #management
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... • Incidence: common ... 500 mg QD until normal ... Differentiation #Syndrome ... #management #hematology
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