17 results
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
Cold Agglutinin ... Cold Agglutinins ... Secondary Cold Agglutinin ... Secondary Cold Agglutinin ... or fingers • Acrocyanosis
Summary Table of Causes of Acrocyanosis:

Dr. Ann Marie Kumfer @AnnKumfer

#Acrocyanosis #Differential #Causes #Diagnosis #Causes #Table
Table of Causes of Acrocyanosis ... @AnnKumfer #Acrocyanosis
Autoimmune Hemolytic Anemia (AIHA) - Differential Diagnosis Table

Warm AIHA (48-70%)
Cold AHA (16-32%)
 • Donath-Landsteiner HA (paroxysmal
hemoglobinuria) • Cold Agglutinin
Common Raynaud's Mimickers
 - Acrocyanosis
 - Chill blains (pernio)
 - Erythromelalgia
 - Frostbite
 - Achenbach's Syndrome

Dr.
Mimickers - Acrocyanosis
perioral cyanosis- A blue color around the lips and philtrum is a relatively common finding shortly
This is part of acrocyanosis ... perioral #cyanosis #acrocyanosis
Expected DAT Results in Autoimmune Hemolysis
DAT Negative Hemolysis
 • DAT Poly ( - ), IgG (
( +/- ) Cold agglutinin
Cutaneous Manifestations of Monoclonal Gammopathy
 • Extravascular lg Deposits: Systemic amyloidosis, Nodular amyloidosis, Macroglobulinoderma, Follicular hyperkeratotic
cryoglobulinemia, Cold agglutinin
Red cell autoagglutination is the process whereby red cells clump together forming aggregates. This is seen
macroglobulinemia, cold agglutinin
Red cell autoagglutination is the process whereby red cells clump together forming aggregates. This is seen
macroglobulinemia, cold agglutinin
Causes of Cyanosis in the Newborn - Differential Diagnosis Algorithm
Peripheral Only:
 • Poor Perfusion
 • Acrocyanosis
Hemoglobinopathy:
Perfusion • Acrocyanosis