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differential ana antibody patterns testing vasculitis anca antibodies antineutrophil disease diseases erythematosus igg4 large lupus medium nuclear phenotypes polychondritis relapsing
Antinuclear Antibody Testing - Nuclear and Cytoplasmic Patterns Nuclear Patterns: • Homogeneous pattern: -
Antinuclear Antibody ... - Nuclear and Cytoplasmic ... #Antinuclear #Antibody ... #differential #diagnosis ... #rheumatology
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
ANA (Antinuclear ... Antineutrophil cytoplasmic ... #Antinuclear #Antibody ... Antineutrophil #antibodies #diagnosis ... #rheumatology #
Antinuclear Antibody Testing Cytoplasmic Patterns Reticular/AMA: • PBC, SSc, PBC/SSc OS, PBC/SjS OS • AMA Speckled: •
Antinuclear Antibody ... Testing Cytoplasmic ... #Testing #Cytoplasmic ... #differential #diagnosis ... #rheumatology
Vasculitis - Break down based on vessel size Distribution of vessel involvement by large vessel vasculitis,
of vessel, from aorta ... left to right) aorta ... antineutrophil cytoplasmic ... #Diagnosis #Rheumatology ... Medium #Large #Classification
Systemic Lupus Erythematosus - Summary Antinuclear (ANA) - 95% - Initial screening test Anti-dsDNA - 50% • Associated
Erythematosus - Summary Antinuclear ... (ANA) - 95% - Initial ... #SLE #Summary #diagnosis ... #rheumatology # ... management
IgG4-Related Disease Clinical history: Man, 60 years, multiorgan involvement, unique or multiple inflammatory pseudotumor 4 phenotypes: •
Retroperitoneum and aorta ... conventional imaging (aorta ... autoantibodies (antinuclear ... #management #phenotypes ... workup #treatment #rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
< 30 years - Aorta ... branches • GCA: - Aorta ... LFT • ESR • ANA ... #rheumatology # ... classification
Relapsing Polychondritis What is it? Recurrent inflammation of the cartilage in the body (Autoimmune disorder) Who? • Most frequently: 40
Large vessels (aorta ... /EGPA • RA Diagnosis ... Nonspecific ↑ ESR, CRP, ANA ... Polychondritis #rheumatology ... #diagnosis #management
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