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ana patterns antibody lupus testing antibodies cytoplasmic nuclear behcet classification comparison dil disease erythematosus polychondritis relapsing signs summary symptoms syndrome
ANA Patterns and Associated Rheumatic Diseases: • Homogeneous: Systemic lupus erythematosus (SLE), Mixed connective tissue disease
ANA Patterns and ... erythematosus (SLE ... Kumfer @AnnKumfer #Antinuclear ... #patterns #rheumatology ... #diagnosis #differential
Antinuclear Antibody Testing - Nuclear and Cytoplasmic Patterns Nuclear Patterns: • Homogeneous pattern: -
Antinuclear Antibody ... • Reticular/AMA ... #Antinuclear #Antibody ... Cytoplasmic #Patterns #differential ... #diagnosis #rheumatology
Systemic Lupus Erythematosus - Summary Antinuclear (ANA) - 95% - Initial screening test Anti-dsDNA - 50% • Associated
Erythematosus - Summary Antinuclear ... (ANA) - 95% - Initial ... #Summary #diagnosis ... #rheumatology # ... management
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Antinuclear Antibodies ... erythematosus (SLE ... Kumfer @AnnKumfer #Antinuclear ... #patterns #rheumatology ... #diagnosis #differential
Antinuclear Antibody Testing Cytoplasmic Patterns Reticular/AMA: • PBC, SSc, PBC/SSc OS, PBC/SjS OS • AMA Speckled: •
Antinuclear Antibody ... Speckled: • SLE ... #Antinuclear #Antibody ... Cytoplasmic #Patterns #differential ... #diagnosis #rheumatology
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
Workup: - ANA ... Usual therapeutic management ... Lupusreference #druginduced ... #table #rheumatology ... #diagnosis #management
Antinuclear Antibody Testing - Nuclear Patterns Homogeneous pattern: • SLE, SSc, AIH, JIA • dsDNA, chromatin,
Antinuclear Antibody ... Homogeneous pattern: • SLE ... pattern: • SjS, SLE ... Nuclear #Patterns #differential ... #diagnosis #rheumatology
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
Behcet disease) Differential ... Oral aphthae : SLE ... • Arthritis: SLE ... #management #signs ... #symptoms #rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
< 30 years - Aorta ... branches • GCA: - Aorta ... LFT • ESR • ANA ... vasculitis, and SLE ... #diagnosis #rheumatology
Drug Induced Lupus (DIL) • Epidemiology: -10% of all lupus cases, drug-dependent, 4:1 to 1:1 F:M
Workup: - ANA ... Lupusreference #DrugInduced ... #Lupus #DIL #rheumatology ... #diagnosis #treatment ... #management
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