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hematology differential workup causes oncology hemolytic hemolysis liver macrocytic summary atlas chronic classification disorders extravascular injury intravascular leukemia lymphocytic macrocytosis
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
RBC) Morphology ... Burr Cell RBC (Echinocyte ... Bite Cell RBC: G6PD ... Target Cell RBC ... #differential #diagnosis
Hemolytic Anemias - Differential Diagnosis Algorithm Signs of anemia and hemolysis: • ↓ Haptoglobin • ↑ LDH
- Differential Diagnosis ... Algorithm Signs ... • Extrinsic RBC ... • Intrinsic RBC ... #Algorithm #hematology
Overall Approach to Anemia - Differential Diagnosis Algorithm Blood Loss • Acute Bleed - Normocytic / Normochromic
Decreased RBC ... Disease • Marrow ... Infiltration Increased RBC ... Thalassemia • RBC ... Disorder • RBC
Common RBC Inclusions and Associations • Howell Jolly Bodies: Hyposplenism, Asplenism, Severe hemolytic anemia • Heinz
Common RBC Inclusions ... : Hemoglobin H disease ... , MDS #RBC #Inclusions ... #Bodies #diagnosis ... #hematology
Anemia Diagnostic Algorithm Mean corpuscular (cell) volume (MCV): Average RBC size. Under 80 = microcytic. Between 80-95
Anemia Diagnostic ... (MCV): Average RBC ... wide range of RBC ... #Algorithm #Diagnosis ... #Workup #Hematology
Red Blood Cell (RBC) Morphology Atlas • Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
Red Blood Cell ( ... RBC) Morphology ... coagulopathy (DIC) #RBC ... Morphology #Atlas #key #diagnosis ... #differential #hematology
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
2) External (RBC ... 3) Internal (RBC ... Defects: Sickle cell ... anemia, Thalassemias ... #hematology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... Algorithm • Sickle ... Consider sickle cell ... hypertension • Unusual RBC ... acanthocytes - Consider RBC
Blood Disorders - Markers and Differential Diagnosis Algorithm Acute • Myloid (AML) - CD13, CD33, CD34,
Algorithm Acute ... Pelger-Huet, Macrocytic anemia ... • Lymphoid (CLL ... bcr-able (+) ↑ WBC ... #Algorithm
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
- Differential Diagnosis ... Algorithm Normal ... Neutrophils - Low RBC ... RBCs in Rouleaux ... #Hematology
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