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Thrombotic Microangiopathies In Systemic Lupus Erythematosus

Dr. Laurent ARNAUD @Lupusreference

#TMAs #Thrombotic #Microangiopathies #Systemic #Lupus #Erythematosus #SLE #hematology
Erythematosus #SLE ... #hematology #rheumatology ... #differential # ... diagnosis #causes
Skin Conditions Associated with Joint Pain

Rash
	• Human parvovirus B19 infection

Malar rash
	• SLE
	• Human parvovirus B19 infection
	•
Associated with Joint ... Pain Rash ... infection Malar rash ... #rashes #differential ... #diagnosis #rheumatology
Top 10 situations when to think about lupus
1) Inflammatory joint pain (especially in the wrists and
) Inflammatory joint ... everywhere) 2) A rash ... the face (many differential ... #sle #clues #system ... erythematosus #rheumatology
Approach to Joint Pain - Diagnostic Framework

1) Chronicity
2) Inflammatory vs Non-Inflammatory
3) Number of Joints Involved

1) Chronicity:
Pain - Diagnostic ... Like in this case ... Chronic = RA, SLE ... #rheumatology # ... approach #workup #differential
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary
 • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
) - Diagnosis and ... Manifestations: Malar rash ... Positive in 60-80% of cases ... Erythematosus #Diagnosis ... #rheumatology
Causes of Bone/Joint Pain in Sickle Cell Disease
Vaso-occlusive pain:
 • Mechanism: ischemic pain
 • Can present
Causes of Bone/Joint ... dz difficult to see ... • Differentiate ... #diagnosis #causes ... #hematology
Causes of Thrombocytopenia - Differential Diagnosis Algorithm
 
Decreased Megakaryopoiesis
 • Aplastic Anemia
 • Toxic Damage (e.g.
Causes of Thrombocytopenia ... - Differential ... Diagnosis Algorithm ... Autoimmune • ITP • SLE ... #Causes #Hematology
Causes of Polyneuropathy - Differential Diagnosis Algorithm
 • Metabolic: DM, Hypothyroidism, CKD, Cirrhosis, Nutritional deficiency
 •
- Differential ... Diagnosis Algorithm ... • Toxic: EtOH, Meds ... Paraneoplastic, CTD (SLE ... Mitochondrial issues - VA Joint
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Purpura - Differential ... Diagnosis Framework ... Associated - SLE ... #Diagnosis #hematology ... #rheumatology #
Clinical Features of Systemic Lupus (SLE)
General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%)
Eye: Sjögrens (15%)
Skin
Systemic Lupus (SLE ... Photosensitivity, Butterfly rash ... phenomenon (20%) Joints ... signs #symptoms #diagnosis ... #rheumatology