22 results
Glomerular Diseases - Nephritic and Nephrotic Syndromes

Nephritic syndrome—due to GBM disruption. 
Hypertension. t BUN and creatinine.
Glomerular Diseases ... RBC casts in urine ... may be in nephrotic ... #Classification ... #Proteinuria #Nephrology
Nephritic vs Nephrotic Syndrome

Step 1: If the patient has hematuria and/or proteinuria, think about nephrotic/nephritic syndromes.
Step
the patient have glomerular ... hematuria (RBC casts ... dysmorphic RBCs in ... Syndrome #Comparison #Algorithm ... #Nephrology #Diagnosis
Causes of Acute Kidney Injury - Differential Diagnosis Framework 
Pre-Renal
Post-Renal
Intrinsic Renal:
 • Tubules (ATN)
 • Glomerular:
Causes of Acute ... ) • Glomerular ... : Nephrotic, Nephritic ... Interstitium (AIN ... Differential #Diagnosis #Algorithm
Algorithm - Approach to the differential diagnosis of the patient presenting with overt glomerular proteinuria. CMV
Algorithm - Approach ... Nephrocalcinosis causes ... #Algorithm #differential ... #proteinuria #nephrotic ... #syndrome #nephrology
Rapidly Progressive Glomerulonephritis (RPGN) 
 - Loss of kidney function over a short period of tirne
proliferation in ... glomeruli • Ex ... nephropathy, lupus nephritis ... Glomerulonephritis #RPGN #Classification ... Differential #Diagnosis #Nephrology
Acute Kidney Injury - Classification
Prerenal:
 • Dehydration
 • Heart failure (a.k.a. cardiorenal syndrome)
 • Liver failure
- TTP/HUS • Glomerular ... tubular necrosis (causes ... Acute interstitial nephritis ... (AIN) Postrenal ... #diagnosis #nephrology
Algorithmic Approach to Acute Interstitial Nephritis
When to suspect AIN? (not sensitive)
 • AKI, AKD, rapidly progressive
Algorithmic Approach ... Acute Interstitial Nephritis ... #Interstitial #Nephritis ... #AIN #Algorithm ... #nephrology #diagnosis
Atlas of Urine Microscopy Findings
 • Epithelial cells - Normal
 • Renal tubular cells - Acute
red - cells Non-glomerular ... Dysmorphic red cells - Glomerular ... Diagnostic of glomerular ... brown cast” - Necrotic ... key #diagnosis #nephrology
Hematuria Workup and Diagnosis Algorithm
 • Confirm hematuria → Urinalysis >3 RBCs/HPF, exclude mimics, repeat testing
and Diagnosis Algorithm ... unilateral flank pain ... • Evidence of glomerular ... → Refer to Nephrology ... if cause not identified
Management of Lupus Nephritis
Lupus nephritis (LN) in 10 to 40% of SLE
Hallmark = proteinuria 20.5 g/g
(LN) in 10 to 40% ... severity (ISN/RPS classification ... by 12 months Classification ... Focal LN (<50% of glomeruli ... #rheumatology #nephrology