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Allopurinol Pharmacology Summary

Xanthine oxidase inhibitor blocking the formation of new uric acid
Initiate 1-2 days prior to
Allopurinol Pharmacology ... the kidney #Allopurinol
Allopurinol and its active metabolite inhibit xanthine oxidase, the enzyme that converts hypoxanthine to xanthine and
Allopurinol and ... the effects of allopurinol
Medications for Prevention of Chronic Gout
Colchicine (Colcrys)
Pegloticase (Krystexxa)
Probenecid
Xanthine oxidase inhibitors:
 - Allopurinol (Zyloprim)
 - Febuxostat (Uloric)
#Chronic
inhibitors: - Allopurinol
Role of Uric Acid in the Inflammation of Gout

Allopurinol, Febuxostat - Xanthine oxidase
Colchicine - Release of
Inflammation of Gout Allopurinol
Stevens Johnson Syndrome and Toxic Epidermal Necrolysis - Causative Medications 
and Level of Suspicion 

High Risk:
Antigout:
Risk: Antigout: allopurinol
Drugs that Cause Fever
Most commonly:
Amphotericin B, Antihistamines, Asparaginase, Barbiturates, Bleomycin sulfate, Methyldopa, Penicillins, Phenytoin sodium, Procainamide,
Occasionally: Allopurinol
Lymphadenopathy - Differential Diagnosis Algorithm
Localized: 
 • Cervical: EBV, CMV, HIV, Toxo, TB, Lymphoma, Head /
• Medications: Allopurinol
Approach to Gout
Diagnosis: r/o septic arthritis! Needle-shaped, negative birefringent crystals
Treatment:
 • Weight loss, diet, d/c culprit
Oxidase Inhibitors (Allopurinol
Classification of Tumor Lysis Syndrome (TLS) and Treatment of Metabolic Abnormalities of TLS
Laboratory TLS:
 • Uric
Hyperuricemia - Allopurinol
Medications for Recurrent Calcium Oxalate (CaOx) Stones
HYPERCALCIURIA
 • Thiazides: HCT, Indapamide, Chlorthalidone
 • Consider after first
normal UCa) • Allopurinol