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SLICC SLE Diagnostic Criteria - Systemic Lupus Erythematosus
Clinical and Immunologic Criteria

CLINICAL CRITERIA
 - ACUTE CUTANEOUS LUPUS
SLICC SLE Diagnostic ... Lupus Erythematosus ... Criteria CLINICAL ... - NON-SCARRING ALOPECIA ... SEROSITIS - RENAL - NEUROLOGIC
EULAR/ACR Classification Criteria for Systemic Lupus Erythematosus
Clinical Domains:
 • Constitutional domain: Fever
 • Cutaneous domain: Non-scarring
Classification Criteria ... Clinical Domains ... : Non-scarring alopecia ... least 2 joints • Neurologic ... #SLE #Systemic
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Suspect: Clinical ... and permanent alopecia ... Clinical Features ... Shrinking lung syndrome ... • Nonscarring alopecia
Antinuclear Antibodies (ANA)
ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Antinuclear Antibodies ... likely it will be clinically ... Syndrome (SS), ... Arthritis, Sjögren Syndrome ... Kumfer @AnnKumfer #Antinuclear
Antinuclear antibodies and Systemic lupus
Anti-dsDNA	60-80%	Association with disease activity (when with Farr assay) and lupus nephritis. Can
Antinuclear antibodies ... is clinically suspected ... overlap syndromes ... Lupusreference #Antinuclear ... Systemic #lupus #erythematosus
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
develops on the background ... Clinical Presentation ... Fever is the main clinical ... [SLE], AOSD) • ... Histopathologic criteria
CNS Manifestations of Systemic Lupus Erythematosus (SLE)

Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Systemic Lupus Erythematosus ... (SLE) Clinical ... Demyelinating Syndrome ... Systemic #Lupus #Erythematosus ... #SLE #CNS #neurology
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases

• Septic arthritis - Gram stain and culture of
Systemic lupus erythematosus ... (SLE) - Antinuclear ... • Hepatitis B serology ... Hepatitis B and C serology ... ANA and RF (if clinical
Blood Culture-Negative Infective Endocarditis (BCNIE)
Definition: No etiology found after 3 separate blood cultures remain negative for
antimicrobials, clinical ... factors: - Serology ... See charts - ... Assays for antinuclear ... antiphospholipid syndrome