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Monoclonal Gammopathy of Clinical Significance (MGUS) - Differential Diagnosis Neurologic-Centered: (+) Systemic Features: POEMS, AL amyloid, Cryoglobulinemia
Gammopathy of Clinical ... Features: POEMS, AL amyloid ... • Organized Ig deposits ... : Ig-related amyloid ... Monoclonal #Gammopathy #Clinical
This image shows spicular amyloid deposits showing blunt conical formations with interconnecting fibrils. Dr. Stephen Bonsib via
shows spicular amyloid ... deposits showing ... arkanalabs #amyloid ... #deposits #deposition ... ElectronMicroscopy #SEM #clinical
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 This image shows a glomerular tuft with overall intact architecture. Discrete masses of specular amyloid (long
masses of specular amyloid ... capillary loop (short ... #glomerulus #amyloid ... #desposition #deposits ... ElectronMicroscopy #SEM #clinical
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 Great Mimickers - SHALLOTS Mnemonic S- Syphilis - Neurosyphilis, aortitis, gummas... Granulomas can form anywhere! Skin, mucosa,
A - Amyloid - Amyloid ... deposits everywhere
This image shows spicular amyloid with tapering conical masses interconnected by branching fibrils! Dr. Stephen Bonsib via
shows spicular amyloid ... with tapering conical ... arkanalabs #amyloid ... #desposition #deposits ... ElectronMicroscopy #SEM #clinical
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 Rapidly Progressive Glomerulonephritis (RPGN) - Loss of kidney function over a short period of tirne
function over a short ... Presence of immune deposits ... on IF • No EM deposits ... Minimal immune deposits
Osteoarthritis (OA): X-ray features - Joint space narrowing (least specific) - Subchondral Cysts (pockets of
(Abnormal bone deposits ... /spurs surrounding ... diagnosis #findings #Clinical
Amyloidosis - Summary Group of disorders associated with extracellular deposition of fibrils formed from low-molecular-weight proteins in
Amyloidosis: • Primary amyloid ... Clinical suspicion ... Amyloidosis Clinical ... Bone/Joint: • Amyloid ... (AMYLOID ANGIOPATHY
This image shows portions of glomerular tuft with collapsed GBM (across top), spicular amyloid (middle right),
top), spicular amyloid ... ), and nodular amyloid ... glomerulus #GBM #amyloid ... #desposition #deposits ... ElectronMicroscopy #SEM #clinical
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 Cutaneous Manifestations of Monoclonal Gammopathy • Extravascular lg Deposits: Systemic amyloidosis, Nodular amyloidosis, Macroglobulinoderma, Follicular hyperkeratotic
Extravascular lg Deposits ... Intravascular lg deposits ... dermatology #skin #clinical
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