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Monoclonal Gammopathy of Clinical Significance (MGUS) - Differential Diagnosis Neurologic-Centered: (+) Systemic Features: POEMS, AL amyloid, Cryoglobulinemia
Features: POEMS, AL amyloid ... • Organized Ig deposits ... : Ig-related amyloid ... Non-organized Ig deposits ... monoclonal Ig deposits
Nephrotic Syndrome - Classification - Podocytopathies - Immunocomplex Deposits - Other substances Deposits #Nephrotic #Syndrome
Immunocomplex Deposits ... Other substances Deposits
Great Mimickers - SHALLOTS Mnemonic S- Syphilis - Neurosyphilis, aortitis, gummas... Granulomas can form anywhere! Skin, mucosa,
A - Amyloid - Amyloid ... deposits everywhere
This image shows spicular amyloid deposits showing blunt conical formations with interconnecting fibrils. Dr. Stephen Bonsib via
shows spicular amyloid ... deposits showing ... arkanalabs #amyloid ... #deposits #deposition
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 Alzheimer’s Disease: Pathogenesis and Clinical Findings Risk factor for Late Onset Alzheimer's (99% of cases): - Increasing
of cases): - Amyloid ... Down syndrome (amyloid ... AlzheimersDisease #Dementia #pathophysiology
Amyloidosis - Summary Group of disorders associated with extracellular deposition of fibrils formed from low-molecular-weight proteins in
Amyloidosis: • Primary amyloid ... dyscrasias • Secondary amyloid ... Bone/Joint: • Amyloid ... (AMYLOID ANGIOPATHY ... Protein • AL Amyloid
Membranoproliferative Glomerulonephritis (MPGN) AKA: Mesangiocapillary GN • Active Urine Sediment (dysmorphic RBC, RBC casts, +/- proteinuria)
glomerulopathy (Dense deposit ... Minimal immune deposits
Cutaneous Manifestations of Monoclonal Gammopathy • Extravascular lg Deposits: Systemic amyloidosis, Nodular amyloidosis, Macroglobulinoderma, Follicular hyperkeratotic
Extravascular lg Deposits ... Intravascular lg deposits
Type III Hypersensitivity: Pathogenesis and clinical findings Definition: Small antigen-antibody complexes (produced from normal immune response to
foreign substances) deposit ... Allergy #Immunology #pathophysiology
This image shows portions of glomerular tuft with collapsed GBM (across top), spicular amyloid (middle right),
top), spicular amyloid ... ), and nodular amyloid ... glomerulus #GBM #amyloid ... #desposition #deposits
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