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Hemolytic Anemias - Differential Diagnosis Algorithm

Signs of anemia and hemolysis:
 • ↓ Haptoglobin
 • ↑ LDH
Hemolytic Anemias ... Algorithm Signs of anemia ... Anemias (AIHAs) ... Anemias (AHAs) ... #Anemias #Differential
Hemolytic Anemia - Hemolysis Diagnostic Workup

Infographic by: Howard Ong

#Hemolysis #Hemolytic #Anemia #Algorithm #MAHA #TTP #Diagnosis #Workup
Hemolytic Anemia ... - Hemolysis Diagnostic ... Howard Ong #Hemolysis ... #Hemolytic #Anemia
Anemia - Hemolysis Diagnostic Algorithm
Autoimmune hemolytic anemia
Microangiopathic hemolytic anemia
Probable thalassemia

Dr. Eric Strong @DrEricStrong - Strong Medicine
Anemia - Hemolysis ... Algorithm Autoimmune hemolytic ... anemia Microangiopathic ... hemolytic anemia ... #Anemia #Algorithm
Laboratory Testing in Hemolytic Anemia

Intravascular vs Extravascular Hemolysis
Reticulocytes
Unconjugated bilirubin
LDH
Peripheral smear
Haptoglobin
Urine hemosiderin
Urine hemoglobin
Carboxyhemoglobin

#Hemolytic #Anemia #Laboratory #Testing #workup
Laboratory Testing in Hemolytic ... Anemia Intravascular ... Extravascular Hemolysis ... Carboxyhemoglobin #Hemolytic ... #Anemia #Laboratory
Algorithm for the Diagnosis and Workup of Hemolytic Anemia

By Dr. Kylie Adamek @KylieAdamek

#Hemolytic #Anemia #Algorithm #Differential
and Workup of Hemolytic ... Anemia By Dr ... KylieAdamek #Hemolytic ... #Anemia #Algorithm ... Workup #Hematology #Hemolysis
Paraproteinemias

Entities That Can Feature A Monoclonal Protein/M Component:
• MM
• WM
• MGUS
• MGCS
• MGRS
• Splenic Marginal Zone
• Coombs (-) hemolytic ... anemia due to cold ... Differential #Diagnosis #Oncology
Hemolysis - Diagnostic Algorithm and Causes

Increased red cell production: 
 • Increased Reticulocytosis/polychromasia 
 • Erythroid
Hemolysis - Diagnostic ... breakdown • Anaemia ... haptogbbulin #Hemolysis ... #Hemolytic #Anemia
Warm vs Cold Autoimmune Hemolytic Anemia
Warm Autoimmune Hemolytic Anemia:
 • Mechanism: IgG and Complement-mediated
 • Etiology:
Cold Autoimmune Hemolytic ... Anemia Warm Autoimmune ... Hemolytic Anemia ... Anemia: • Mechanism ... #Anemia #hematology
Hemolytic Anemia - Differential Diagnosis Algorithm
Hereditary:
 • Peripheral blood smear + DAT + further History
 •
Hemolytic Anemia ... → Sickle Cell anemia ... Immune mediated hemolysis ... anemia (TTP, HUS ... #Anemia #Differential
Differential diagnosis of schistocytes / fragmentation hemolysis:
 • Thrombotic microangiopathies (TMA)
    - TTP
fragmentation hemolysis ... toxin-mediated hemolytic-uremic ... • Mechanical hemolysis ... macroangiopathic hemolytic ... anemia" • HELLP