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diagnosis causes hematology algorithm dermatology erythematosus sle systemic ana antibodies antinuclear autoantibodies bruising classification disease joint pain skin thrombocytopenia agglutinin
Autoantibodies in Rheumatology • Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and
Autoantibodies in Rheumatology ... • Lupus (SLE): ... glycoprotein I (ß2GP), Lupus ... Polymerase Ill • ANCA Vasculitis ... #diagnosis #associations
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
- Diagnosis Manifestations ... (aPL) 30-45% Differential ... Diagnosis and Lupus ... symptoms #mimickers #differential ... #rheumatology
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
Post-strep GN, Lupus ... Glomerulonephritis #Vasculitis ... #differential # ... diagnosis #algorithm ... #rheumatology
Vasculitis - Break down based on vessel size Distribution of vessel involvement by large vessel vasculitis,
Vasculitis - Break ... by large vessel vasculitis ... Anti-GBM = anti–glomerular ... #Diagnosis #Rheumatology ... #Differential #
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
) • Systemic lupus ... ANCA-Associated Vasculitis ... Renal-limited vasculitis ... Antineutrophil #antibodies #diagnosis ... #rheumatology #
Vasculitis Involving the Skin - Differential Diagnosis Framework Primary: 50% Cutaneous Vasculitis: Leukocytoclastic Vasculitis Secondary: CTD: SLE, RA
the Skin - Differential ... Diagnosis Framework ... Ig A (HSP) - Anti-C1q ... #dermatology #rheumatology ... diagnosis
Pulmonary Renal Syndrome Definition: Diffuse alveolar hemorrhage + Glomerulonephritis Presentation (Pulmonary and renal manifestations can occur weeks apart):
symptomatology Differential ... Diagnosis for Pulmonary ... Complex: Systemic lupus ... Renal #Syndrome #differential ... #diagnosis #nephrology
Seronegative Inflammatory Arthritis - Differential Diagnosis • Seronegative Rheumatoid Arthritis • Infectious Arthritis: Viral, Bacterial,
Inflammatory Arthritis - Differential ... Diagnosis • Seronegative ... Disease: Systemic Lupus ... Erythematous, Systemic Vasculitis ... #Diagnosis #rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
(anti-C1q Vasculitis ... such as systemic lupus ... testes -> pain, infarct ... differential #diagnosis ... #rheumatology #
Myositis and Myopathies Polymyositis • Progressive, symmetric muscle weakness • Elevated CK, +Anti-Jo, +Anti-Mi2 Dermatomyositis
, Gemcitabine Lupus ... uncommon 5-15% of lupus ... Myopathies #myopathy #differential ... #diagnosis #comparison ... #rheumatology
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