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algorithm extravascular hemolysis hemolytic peds aplastic bruising chronic classification emesis fatigue management neutropenia oncology purpura thrombocytopenia vomiting
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
Causes of Extravascular ... delayed HTR • Drug-induced ... • PNH • Drug-induced ... #Differential #Diagnosis ... #Hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Causes Intravascular ... infection) - Drugs ... (Beta lactam antibiotics ... #Causes #differential ... #diagnosis #hematology
Differential Diagnosis for Hemolytic Anemia Intrinsic Causes: • Enzyme deficiencies ex. G6PD, pyruvate kinase • Hemoglobinopathies
Differential Diagnosis ... AIHA: warm, cold, drug ... IVIG infusion Intravascular ... Diagnosis #causes ... classification #hematology
Causes of Fatigue - Differential Diagnosis Algorithm Endocrine • Hypo/Hyperthyroidism • Diabetes • Pituitary Insufficiency • Adrenal
Neoplastic / Hematologic ... • Anemia • ... Anti-Depressants • Drug ... Alcohol) • Drug ... Malnutrition / Drug
Pediatric Vomiting - Gastrointestinal and Systemic Causes - Differential Diagnosis Algorithm Hepatobiliary: • Acute Hepatitis • Acute
Pediatric Vomiting ... - Differential ... Diagnosis Algorithm ... Tract Infection Drugs ... Chemotherapy • Antibiotics
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
- Overview Who ... and petechiae Causes ... Dyskeratosis congenita • Drugs ... - Cytotoxic drugs ... Treatment:
Causes of Neutropenia - Differential Diagnosis Neonate: - Infection - by far the most common cause -
hypertension and/or drug ... Idiosyncratic drug ... Idiosyncratic drug ... #diagnosis #causes ... #hematology
Causes of Purpura or Easy Bruising in Children Platelet count reduced, i.e. thrombocytopenia - Increased platelet destruction
Causes of Purpura ... (disseminated intravascular ... leukaemia) - Drug-induced ... #peds #pediatrics ... #diagnosis #differential
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