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diagnosis algorithm mcv neutropenia calculation classification deficiency extravascular folicacid hemolytic index intravascular management nutrition oncology pancytopenia production reticulocyte thrombocytopenia
Causes of Neutropenia with Pancytopenia - Differential Diagnosis Algorithm Sequestration: • Splenomegaly Marrow Infiltration: • Hematologic and non-hematologic
Causes of Neutropenia ... Radiation • Drugs ... • Toxins • Aplastic ... Anemia • Myelodysplasia ... deficiency: • B12/folate
Causes of Thrombocytopenia - Differential Diagnosis Algorithm Decreased Megakaryopoiesis • Aplastic Anemia • Toxic Damage (e.g.
Megakaryopoiesis • Aplastic ... Anemia • Toxic ... methotrexate) • Drugs ... anti-HLA antibodies Drugs ... #Hematology
Algorithmic Approach to Anemia - Differential Diagnosis Framework by MCV Microcytic (MCV < 80) "TAILS": • Thalassemia
- Differential ... : ACD, Aplastic ... Megaloblastic: Folate ... Orotic aciduria, Drugs ... #Diagnosis #hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
anemia): ... infection) - Drugs ... (Beta lactam antibiotics ... #differential # ... diagnosis #hematology
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Low Mean Corpuscular Volume (<80
Causes of Anemia ... • Bleeding • Hemolysis ... Deficiency • Folate ... Deficiency • Drugs ... #Hematology
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor The maturation factor is
, Vitamin B12, Folate ... marrow failure: Aplastic ... suppression (e.g. drugs ... Production #Index #hematology ... #anemia #differential
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Aplastic Anemia ... - Overview Who ... Dyskeratosis congenita • Drugs ... - Cytotoxic drugs ... anemia Treatment
Etiologies of Folate Deficiency • Decreased dietary intake - uncommon in this era • Increased requirements
pregnant have hemolytic ... anemia, or psoriasis ... that can cause ... Malabsorption • Drugs ... #diagnosis #hematology
Causes of Neutropenia - Differential Diagnosis Neonate: - Infection - by far the most common cause -
hypertension and/or drug ... treatment - Maternal ... Idiosyncratic drug ... Idiosyncratic drug ... #hematology
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