22 results
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... Extravascular Causes ... ) (e.g. lupus, CLL ... , lymphoma, idiopathic ... #hematology #anemia
Causes of Splenomegaly - Differential Diagnosis Algorithm
Infectious
 • Bacterial
 • Viral (EBV)
 • Parasitic
 • Fungal
Congestive
Infectious • Bacterial ... Malignant • Lymphoma ... Serum Sickness Hemolytic ... Cell Disease (children ... #Hematology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm

Peripheral Smear concerning for malignancy?
→ Refer to hematology ... blood loss, Acute hemolysis ... Metastatic cancer, Lymphoma ... Kawasaki, Nephrotic syndrome ... #Algorithm #hematology
Leukemias Overview: ALL, CML, AML, APML, CLL

Acute leukemias > 20% blasts in the peripheral blood smear
extramedullary disease ... • Tumor lysis syndrome ... Lymphoma (SLL) ... #Hematology #Oncology ... #Diagnosis
Chronic Lymphocytic Leukemia - Summary

Cancer affecting lymphocytes/Mature B cell neoplasm
 • Lymphocytes accumulate in large numbers
Diagnosis: • ... cells can indicate disease ... and other C Cell ... #workup #oncology ... #hematology
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary
myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Myelodysplastic Syndrome ... and Management ... old, ~10,000 new cases ... Allogeneic stem cell ... #hematology #oncology
Multiple Myeloma and Monoclonal Gammopathies
C - HyperCalcemia- calcium > 11 mg/dL / >1 mg/dL the ULN
R
, B and T cell lymphoproliferative ... diseases, CML, ... plasmacytoma, POEMs syndrome ... Gammopathies #MGUS #diagnosis ... #hematology #oncology
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
Cold Agglutinin Syndrome ... autoimmune disorder or lymphoid ... - Monoclonal - Lymphoid ... Diagnosis: • hemolytic ... #hematology #diagnosis
Thrombocytopenia and Pregnancy - TTP/HUS, HELLP Syndrome and Acute Fatty Liver of Pregnancy (AFLP)
Three syndromes in
the critically ill ... defects. 1) HELLP (Hemolysis ... child * Severe cases ... AFLP #obstetrics #hematology ... #diagnosis #table
Common Variable Immunodeficiency (CVID)

What?
CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
to impaired B-cell ... autoimmune hemolytic ... DDX - Other causes ... hypogammaglobulinemia #immunology #hematology ... #diagnosis #management