24 results
Autoimmune Hemolytic Anemia (AIHA) - Differential Diagnosis Table

Warm AIHA (48-70%)
Cold AHA (16-32%)
 • Donath-Landsteiner HA (paroxysmal
Autoimmune Hemolytic Anemia ... (AIHA) - Differential ... Donath-Landsteiner HA (paroxysmal ... #AIHA #Differential ... Diagnosis #Table #hematology
Differential Diagnosis for Hemolytic Anemia
Intrinsic Causes:
 • Enzyme deficiencies ex. G6PD, pyruvate kinase 
 • Hemoglobinopathies
Differential Diagnosis ... • AIHA: warm, cold ... incompatibility • Paroxysmal ... Diagnosis #causes #classification ... #hematology
Expected DAT Results in Autoimmune Hemolysis
DAT Negative Hemolysis
 • DAT Poly ( - ), IgG (
, C3d ( +/- ) Cold ... , C3d ( +/- ) Paroxysmal ... cold hemoglobinuria ... #antiglobulin #test ... Autoimmune #Hemolysis #hematology
Red Blood Cell (RBC) Morphology
Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
Iron deficiency anemia ... Cell Agglutinate: Cold ... , Paroxysmal cold ... RBC #Morphology #differential ... #diagnosis #hematology
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
younger pts) Differential ... macroglobulinemia Paroxysmal ... • Diagnostic Test ... Donath-Landsteiner test ... #hematology #diagnosis
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
Transfusion reaction, Paroxysmal ... Autoimmune (AIHA)"Cold ... (e.g. primary cold ... Extravascular #Causes #differential ... #anemia
Pancytopenia - Differential Diagnosis

Congenital Diseases:
• GATA2 deficiency
• Fanconi’s anemia
• Wiskott-Aldrich syndrome
• Ribosomopathy or telomeropathy

Cancer:
• Leukemia
• Lymphoma

Inflammatory
Pancytopenia - Differential ... deficiency • Fanconi’s anemia ... erythematosus • HLH • Paroxysmal ... #Pancytopenia #Differential ... #Diagnosis #Hematology
Hemolysis - Diagnostic Algorithm and Causes

Increased red cell production: 
 • Increased Reticulocytosis/polychromasia 
 • Erythroid
breakdown • Anaemia ... Hemolysis #Hemolytic #Anemia ... #Algorithm #Differential ... Causes #Workup #Hematology ... GrepMed Recommended Text
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Low Mean Corpuscular Volume (<80
Causes of Anemia ... Volume (MCV) - Differential ... #MCV #Classification ... #Differential # ... Algorithm #Causes #Hematology
Overall Approach to Anemia - Differential Diagnosis Algorithm

Blood Loss
 • Acute Bleed - Normocytic / Normochromic
Overall Approach to Anemia ... - Differential ... #Classification ... #Approach #Differential ... Algorithm #Causes #Hematology