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diagnosis lupus sle hematology syndrome systemic treatment differential neurology signs symptoms activation apml arteritis behcet causes cerebritis chemicalinjury coagulation comparison
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
CNS Manifestations ... Systemic Lupus Erythematosus ... Disease, PRES Pathophysiology ... #rheumatology # ... cerebritis #diagnosis #management
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Systemic Lupus Erythematosus ... Diagnosis and Management ... - CRP: Usually normal ... lupus #Systemic #Erythematosus ... #Summary #rheumatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
sedimentation rate + Normal ... Non-autoimmune rheumatologic ... • May involve PNS ... and CNS • Headache ... #Diagnosis #Rheumatology
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
basal ganglia, CNS ... meningitis), MCC CNS ... inhibitors • Uveitis- Ophthalmology ... Syndrome #diagnosis #management ... signs #symptoms #rheumatology
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
protein C and S Pathophysiology ... Thromboembolism (7%) • CNS ... - APTT < 1.5 x normal ... causes #treatment #management ... #hematology
Optic Neuritis - Diagnosis and Management • Epidemiology: Female (75%), 18-50 years, caucasian • Symptoms: Moderate visual
Diagnosis and Management ... lesions (a), Brain: normal ... Neuritis #Diagnosis #Management ... #treatment #rheumatology ... #ophthalmology
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
CRP - Usually normal ... Systemic Lupus Erythematosus ... Usual therapeutic management ... comparison #table #rheumatology ... #diagnosis #management
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Systemic lupus erythematosus ... nervous system (CNS ... systemic lupus erythematosus ... Syndrome #Diagnosis #Management ... #Hematology #Rheumatology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
ATRA treatment Pathophysiology ... 500 mg QD until normal ... APML #diagnosis #management ... #hematology #oncology
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
strength & enzymes normal ... ischemia • Skin: Erythematous ... fluid (CSF) is abnormal ... chorioretinitis, CNS ... Differential #Diagnosis #Rheumatology
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