13 results
Anterior ischemic optic neuropathy (AION) - Recognition of giant cell arteritis (GCA)

1) Is visual loss caused
Fundoscopy: optic disc ... Abnormal TAB ... GiantCellArteritis #GCA ... #Rheumatology # ... Ophthalmology #Diagnosis
Central Retinal Artery Occlusion: Pathogenesis and clinical findings
 • Inflammatory Disease: (i.e. GCA, SLE, GPA) ->
GCA, SLE, GPA) - ... congenital defects) -> Abnormal ... anti-coagulation • Hematologic ... Occlusion #CRAO #pathophysiology ... #ophthalmology
Rapidly Progressive Glomerulonephritis (RPGN)
RPGN has three primary pathophysiologic causes differentiated by immunofluorescence

Immune Complex Mediated (granular staining):
three primary pathophysiologic ... Idiopathic • Normal ... ANCA (C-ANCA): GPA ... eGPA, MPA >>> GPA ... diagnosis #algorithm #rheumatology
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
protein C and S Pathophysiology ... Thrombocytopenia - Normal ... - APTT < 1.5 x normal ... causes #treatment #management ... #hematology
Adult-Onset Still's Disease
Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia
+ Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
MAS, Visceral, DIC ... • Muscular: normal ... CK, normal biopsy ... Disease #diagnosis #management ... #treatment #rheumatology
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary
 • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Diagnosis and Management ... of SLE versus DIL ... - CRP: Usually normal ... Usual therapeutic management ... #Summary #rheumatology
Giant cell arteritis (GCA)

Giant cell arteritis (GCA) definition: Most common systemic inflammatory vasculitis in older adults
cell arteritis (GCA ... , but normal values ... them, but urgent rheumatology ... required +/- prompt ophthalmology ... Symptoms #Diagnosis #Management
Drug Induced Lupus vs SLE
Drug Induced Lupus (DIL):
 • Epidemiology: -10% of all lupus cases, drug-dependent,
CRP - Usually normal ... - CRP: Usually normal ... Usual therapeutic management ... comparison #table #rheumatology ... #diagnosis #management
Optic Neuritis - Diagnosis and Management
 • Epidemiology: Female (75%), 18-50 years,
caucasian
 • Symptoms: Moderate visual
Diagnosis and Management ... lesions (a), Brain: normal ... Neuritis #Diagnosis #Management ... #treatment #rheumatology ... #ophthalmology
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
ATRA treatment Pathophysiology ... 500 mg QD until normal ... APML #diagnosis #management ... #hematology #oncology