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Treatment Options for Lupus Nephritis

#Lupus #Nephritis #Treatment #management #nephrology
Treatment Options ... for Lupus Nephritis ... #Lupus #Nephritis ... #Treatment #management ... #nephrology
CNS Manifestations of Systemic Lupus Erythematosus (SLE)

Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Erythematosus (SLE ... Disease, PRES Pathophysiology ... #CNS #neurology ... cerebritis #diagnosis #management ... #treatment
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary
 • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Systemic Lupus Erythematosus ... and Management ... , oral ulcers, Lupus ... - CRP: Usually normal ... life-threatening • Treatment
Systemic Lupus Erythematosus (SLE): Musculoskeletal Manifestations

 • Immune Complex Deposition
    - Arthralgia, Arthritis
Systemic Lupus Erythematosus ... (SLE): Musculoskeletal ... #Systemic #Lupus ... Erythematosus #SLE ... Complications #pathophysiology
Drug Induced Lupus vs SLE
Drug Induced Lupus (DIL):
 • Epidemiology: -10% of all lupus cases, drug-dependent,
CRP - Usually normal ... constitutional symptoms • Treatment ... life-threatening • Treatment ... Usual therapeutic management ... rheumatology #diagnosis #management
Algorithm for the Treatment of Membranous Lupus Nephritis
Sub-nephrotic-range proteinuria (<3.5g/d, normal serum albumin) and Preserved kidney
Algorithm for the Treatment ... of Membranous Lupus ... proteinuria (<3.5g/d, normal ... treat non-renal SLE ... #management #nephrology
Lupus Nephritis Primer
Class I - Minimal Mesangial
Class II - Mesangial Proliferative
Class Ill - Focal Proliferative
Class IV
Lupus Nephritis ... DrFlashHeart #Lupus ... #Nephritis #SLE ... differential #diagnosis #management ... #nephrology
Systemic Lupus Erythematosus (SLE): Pathogenesis

 • Genetic factors (Mutations in HLA- DR2/HLA-DR3 genes, complement genes, cytokine
Systemic Lupus Erythematosus ... (SLE): Pathogenesis ... #Systemic #Lupus ... Erythematosus #SLE ... #Pathophysiology
Systemic Lupus Erythematosus - Summary
Antinuclear (ANA) - 95% - Initial screening test
Anti-dsDNA - 50%
 • Associated
Systemic Lupus Erythematosus ... • Specific for SLE ... severe disease Treatment ... #Systemic #Lupus ... #rheumatology #management
Type III Hypersensitivity: Pathogenesis and clinical findings
Definition: Small antigen-antibody complexes (produced from normal immune response to
(produced from normal ... : • Systemic Lupus ... Erythematosus (SLE ... Allergy #Immunology #pathophysiology