34 results
Systemic Lupus Erythematosus (SLE): Pathogenesis

 • Genetic factors (Mutations in HLA- DR2/HLA-DR3 genes, complement genes, cytokine
Systemic Lupus Erythematosus ... Auto-antibodies -> Abnormal ... Auto-reactive T-cells -> Abnormal ... #Lupus #Erythematosus ... #SLE #Pathophysiology
Systemic Lupus Erythematosus (SLE): Musculoskeletal Manifestations

 • Immune Complex Deposition
    - Arthralgia, Arthritis
Systemic Lupus Erythematosus ... Proximal Weakness, Normal ... Osteoporosis #Systemic ... #Lupus #Erythematosus ... Complications #pathophysiology
CNS Manifestations of Systemic Lupus Erythematosus (SLE)

Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Manifestations of Systemic ... Disease, PRES Pathophysiology ... Puncture, EEG Treatment ... cerebritis #diagnosis #management ... #treatment
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary
 • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Systemic Lupus Erythematosus ... Diagnosis and Management ... - CRP: Usually normal ... life-threatening • Treatment ... #Systemic #Erythematosus
Systemic Lupus Erythematosus - Summary
Antinuclear (ANA) - 95% - Initial screening test
Anti-dsDNA - 50%
 • Associated
Systemic Lupus Erythematosus ... • MCTD (SLE/systemic ... severe disease Treatment ... #Lupus #Erythematosus ... #rheumatology #management
Type III Hypersensitivity: Pathogenesis and clinical findings
Definition: Small antigen-antibody complexes (produced from normal immune response to
(produced from normal ... the cause: • Systemic ... Lupus • Erythematosus ... Allergy #Immunology #pathophysiology
Drug Induced Lupus vs SLE
Drug Induced Lupus (DIL):
 • Epidemiology: -10% of all lupus cases, drug-dependent,
constitutional symptoms • Treatment ... months to years) Systemic ... life-threatening • Treatment ... Usual therapeutic management ... rheumatology #diagnosis #management
Renal involvement in Systemic Lupus Erythematosus (SLE)

Dr. Laurent ARNAUD @Lupusreference

#Renal #lupus #nephritis #SLE #Systemic #Erythematosus #SLE
involvement in Systemic ... Lupus Erythematosus ... nephritis #SLE #Systemic ... Erythematosus #SLE #management ... #treatment
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
Seen in: • Systemic ... lupus erythematosus ... lupus erythematosus ... Treatment: • Corticosteroids ... Syndrome #Diagnosis #Management
Algorithm for the Treatment of Membranous Lupus Nephritis
Sub-nephrotic-range proteinuria (<3.5g/d, normal serum albumin) and Preserved kidney
Algorithm for the Treatment ... of Membranous Lupus ... proteinuria (<3.5g/d, normal ... #Membranous #Lupus ... #management #nephrology