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diagnosis hematology coagulation differential ophthalmology signs symptoms management msk causes laboratory pt complications disseminated intravascular ptt abnormal anticoagulation glaucoma immunology
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
Intravascular Coagulation (DIC ... • Prolonged PT/PTT ... protein C and S Pathophysiology ... PT/INR: ↑ • PTT ... INR < 2.3 - APTT
Coagulation Protein Tests (PT and PTT) #Coagulation #Tests #PTT #algorithm #differential #pathophysiology
Tests (PT and PTT ... Coagulation #Tests #PTT ... #differential #pathophysiology
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Abnormal PT and/or aPTT ... typically prolong aPTT ... may prolong the aPTT ... Prolonged PT and aPTT ... intravascular coagulation (DIC
Prothrombin Time (PT) and Partial Thromboplastin Time (PTT) Prothrombin Time (PT) - Often Elevated in: • Vitamin
Thromboplastin Time (PTT ... Thromboplastin Time (PTT ... elevated in: • DIC ... thematttsai #PT #PTT
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
Prolonged PT and aPTT ... the PT and the aPTT ... intravascularcoagulation (DIC ... #Abnormal #PT #aPTT
ISTH Scoring System for Disseminated Intravascular Coagulation (DIC) Platelet count: • Expected: Low (or normal) • Elevation
Intravascular Coagulation (DIC ... aggregation PT, aPTT ... small vessels #DIC
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
NORMAL PT/NORMAL PTT ... Perform a PTT mixing ... Warfarin • Acute DIC ... the PT and the PTT ... disease • Acute DIC
Therefore, studies obtained at the initial presentation in the emergency department should evaluate for fibrinolysis with
thromboplastin time (PTT ... decompensated DIC ... Diagnosis #Honc #DIC
Disc Herniations - Pathogenesis and Complications • 90% of Lumbar disc herniations happen at L4/5 and L5/S1 •
Disc Herniations ... 90% of Lumbar disc ... 60% of cervical disc ... the vertebral disc ... complications #msk #pathophysiology
Mixing Study • Clotting tests can be abnormal due to either a clotting factor deficiency, or
PT and/or aPTT) ... diagnosis #hematology #pathophysiology
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