66 results
Coagulation Protein Tests (PT and PTT)

#Coagulation #Tests #PTT #algorithm #differential #pathophysiology
Tests (PT and PTT ... Coagulation #Tests #PTT ... #differential #pathophysiology
Approach to Thrombotic Microangiopathy (TMA) - Differential Diagnosis and Management Algorithm

Suspected TMA: Unexplained thrombocytopenia + MAHA
Initial labs: CBC ... antiglobulin test, PT/aPTT ... hemosiderin • PT/aPTT
Pancytopenia - Differential Diagnosis Algorithm
 • 12-13 g/dL,
 • ANC < 1800/uL,
 • platelet < 150,000/uL

Initial
Initial Workup: CBC ... iron studies, PT/aPTT
Chest Pain - Diagnosis and Workup Algorithm

History and Exam
Acute life-threatening causes:
 • Acute myocardial infarction
 •
ultrasound • CXR • CBC ... LET, lipase, PT. aPTT
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
• Prolonged PT/PTT ... protein C and S Pathophysiology ... PT/INR: ↑ • PTT ... INR < 2.3 - APTT
Autoimmune Gastritis - Pathophysiology

Anti-ParietaI Cell, CD4+ T Cells, Autoantibodies -> x Parietal Cells, x HCL, x
Autoimmune Gastritis - Pathophysiology ... Anti-ParietaI Cell, CD4 ... Autoimmune #Gastritis #Pathophysiology
Approach to the Hypercoagulable State
Arterial thromboembolism
→ Cardiac rhythm monitoring, Echocardiogram, Vascular imaging
→ Test for APS, particularly
cancer screening, CBC ... , aPTT, +/- CXR
Standardized Physical Abuse Guideline
<6 months of age
 • Social work consult
 • Skeletal survey
 • Head
appearance • CBC ... , PT, PTT if bruising
Mixing Study
 • Clotting tests can be abnormal due to either a clotting factor deficiency, or
PT and/or aPTT) ... diagnosis #hematology #pathophysiology
C.diff - Clostridioides Difficile Infection (CDI) - Diagnosis and Management - GrepMed Handbook

Clinical Presentation + Progression:
Difficile Infection (CDI ... Perforation) Pathophysiology ... x 10d • 1st CDI ... for recurrent CDI ... IDSA 2021 CDI