66 results
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
Night sweats • Arthralgias ... purpura: Strong sign ... , weight loss, arthralgia ... pulse deficits vascular ... affects the skin, neurologic
Acute Rheumatic Fever: Pathogenesis and Clinical Findings

Delayed autoimmune reaction
-> Molecular mimicry
-> GAS antigen cross-reacts with host
->
Acute Rheumatic Fever ... inflammation • Fever ... • Arthralgia ... Pancarditis and valvular ... pathophysiology #diagnosis #signs
Lyme Disease: Early and Late Clinical manifestations
Stage 1. Localized
 • EM appears 7-14 days at the
Fatigue, myalgia, arthralgia ... , headache, fever ... • Heralded by neurologic ... Remitting, chronic • Neurologic ... Disease #diagnosis #signs
Hypothyroidism – symptoms and signs.

Symptoms: 
Tiredness/malaise, 
Weight gain,
Anorexia,
Cold intolerance, 
Poor memory,
Change in appearance, 
Depression, 
Poor libido,
– symptoms and signs ... coarse skin, Arthralgia ... , Deafness Signs ... Myotonia, Muscular ... Hypothyroid #Features #Signs
Systemic Lupus Erythematosus (SLE): Musculoskeletal Manifestations

 • Immune Complex Deposition
    - Arthralgia, Arthritis
Deposition - Arthralgia ... trabecular thinning -> Avascular ... pathophysiology #signs
Clinical Manifestations of Serotonin Syndrome
 • Ophthalmologic: Mydriasis, Ocular clonus (slow horizontal movements)
 • Gastrointestinal: Diarrhea,
Cardiovascular and vital sign ... : Tachycardia, Fever ... Clonus (inducible), Muscular ... Symptoms #spectrum #signs
Parinaud's Syndrome
What?
 - Impaired upgaze
 - Light-near dissociation
 - Convergence retraction nystagmus
 - Eyelid retraction (Collier's
retraction (Collier's sign ... → "setting sun sign ... " - Vascular disease ... diagnosis #pineal #neurology
Causes of Dizziness - Vertigo - Differential Diagnosis Algorithm
True Vertigo - Illusion of Rotary Movement
Peripheral Vestibular
Dysfunction - Imbalance, neurologic ... symptoms/signs, ... Glomus Tumors - Vascular ... Dizziness #Vertigo #Neurology
Gowers' Sign on Physical Exam

Seen in this patient with Duchenne muscular dystrophy (DMD)

#Gowers #Sign #PhysicalExam #neurology
Gowers' Sign on ... with Duchenne muscular ... DMD) #Gowers #Sign ... #PhysicalExam #neurology ... video #pediatrics #muscular
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Sarcoidosis 
Non-caseating granulomas (Composed of T-helper & inflammatory cells) 
Clinical:
 • Disease fatal in 10% of
Constitutional: Fever ... exertion • Neurologic ... Diagnosis #Symptoms #Signs