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diagnosis hematology differential oncology causes hemolysis treatment workup leukemia aplastic arteritis chronic erythematosus extravascular gca giantcell intravascular lupus lymphocytic mds
Hemolysis - Diagnostic Algorithm and Causes Increased red cell production: • Increased Reticulocytosis/polychromasia • Erythroid
Hemolysis - Diagnostic ... Algorithm and Causes ... #Hemolytic #Anemia ... #Algorithm #Differential ... Causes #Workup #Hematology
Differential diagnosis of schistocytes / fragmentation hemolysis: • Thrombotic microangiopathies (TMA) - TTP
syndrome (ST-HUS ... organ or stem cell ... anemia" • HELLP ... syndrome • Catastrophic ... differential #diagnosis #hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
anemia): ... uremic syndrome ... ) (e.g. lupus, CLL ... differential #diagnosis #hematology ... #anemia
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
Differential Diagnosis Algorithm ... • Sickle cell ... anemia • ... Differential #Diagnosis #Algorithm ... #Causes #Hematology
Red Blood Cell (RBC) Morphology Atlas • Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
Myelodysplastic syndrome ... spherocytosis, Hemolytic ... Schistocytes - Hemolytic ... uremic syndrome ... #differential #hematology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Cold Agglutinin Syndrome ... of anemia include ... anemia • Cold ... malignancies -> CLL ... #anemia #hematology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
ALL Symptoms: ... - infiltrates (anemia ... • Tumor lysis syndrome ... ) CLL Symptoms: ... #Leukemia #Hematology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... Differential Diagnosis Algorithm ... Consider sickle cell ... #Anemia #Differential ... #workup #hematology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
→ Refer to hematology ... blood loss, Acute hemolysis ... , deficiency anemia ... Kawasaki, Nephrotic syndrome ... #hematology
Causes of Thrombocytopenia - Differential Diagnosis Algorithm Decreased Megakaryopoiesis • Aplastic Anemia • Toxic Damage (e.g.
Differential Diagnosis Algorithm ... Megakaryopoiesis • Aplastic Anemia ... ITP • SLE • CLL ... Non-lmmune: • HELLP Syndrome ... #Causes #Hematology
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