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abnormal arterial prolonged pt thrombosis venous anemia bleeding bruising clots ddimer dic embolism extravascular hemolysis hemolytic hemostasis management thromboticthrombocytopenicpurpura treatment
D-dimer Plasma D-dimer is a product of clot breakdown, released upon degradation of polymerized, crosslinked fibrin. Elevated
adjusted d-dimer ... 88 = age adjusted ... #dimer #pathophysiology ... #hematology #differential ... #diagnosis #age
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
Disseminated Intravascular ... protein C and S Pathophysiology ... INR < 2.3 - APTT ... #Coagulation #diagnosis ... #management #hematology
Causes of Arterial and Venous Thrombosis - Differential Diagnosis Framework STRUCTURAL: - PFO: paradoxical emboli - Popliteal
Causes of Arterial ... Diagnosis Framework ... endocarditis) - Disseminated ... intravascular coagulation ... #hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Causes Intravascular ... anemia): - Disseminated ... intravascular coagulation ... #Causes #differential ... #diagnosis #hematology
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Causes of Abnormal ... Disseminated intravascular ... coagulation (DIC ... #diagnosis #differential ... #hematology #coagulation
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
Differential Diagnosis ... are both prolonged ... hemorrhage • Disseminated ... #diagnosis #differential ... #hematology #coagulation
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework VENOUS THROMBOSIS • Acquired Risk Factors: - >48 hours
Diagnosis Framework ... thrombocytopenia - Disseminated ... intravascular coagulation ... Venous #Arterial #pathophysiology ... #hematology #differential
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura Activity of von Willebrand factor-cleaving protease activity - A
performed PT, PTT ... products or D-dimer ... reflection of intravascular ... WBC count and differential ... #Workup #Hematology
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
Diagnosis Framework ... liver failure, disseminated ... intravascular coagulation ... discern these causes ... #Diagnosis #Hematology
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