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Causes of Arterial and Venous Thrombosis - Differential Diagnosis Framework

STRUCTURAL:
 - PFO: paradoxical emboli
 - Popliteal
Causes of Arterial ... and other sites ... endocarditis) - Disseminated ... intravascular coagulation ... #hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
Causes Intravascular ... anemia): - Disseminated ... intravascular coagulation ... #Causes #differential ... #diagnosis #hematology
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
Disseminated Intravascular ... protein C and S Pathophysiology ... INR < 2.3 - APTT ... #Coagulation #diagnosis ... #management #hematology
Causes of Bleeding / Bruising - Differential Diagnosis Algorithm
Thrombocytopenia - Quantitative Defect
 • Decreased Production
 •
Causes of Bleeding ... Diagnosis Algorithm ... Deficiency • Disseminated ... Intravascular Coagulation ... #Causes #Hematology
Causes of Abnormal PT and/or aPTT
Prolonged Prothrombin Time (PT)
1. Acquired deficiency of FVII
Causes of Abnormal ... Disseminated intravascular ... coagulation (DIC ... #diagnosis #differential ... #hematology #coagulation
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework

VENOUS THROMBOSIS

 • Acquired Risk Factors:
	- >48 hours
- Differential ... thrombocytopenia - Disseminated ... intravascular coagulation ... Venous #Arterial #pathophysiology ... #hematology #differential
Differential Diagnosis for a Prolonged PT and aPTT
If the PT and the aPTT are both prolonged,
Differential Diagnosis ... the PT and the aPTT ... hemorrhage • Disseminated ... #diagnosis #differential ... #hematology #coagulation
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework

== Quantitative or Qualitative defect in
associated with thrombosis ... liver failure, disseminated ... intravascular coagulation ... discern these causes ... #Diagnosis #Hematology
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura

Activity of von Willebrand factor-cleaving protease activity - A
Evaluation for Thrombotic ... performed PT, PTT ... reflection of intravascular ... WBC count and differential ... #Workup #Hematology