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diagnosis hematology causes intravascular prolonged pt abnormal disseminated algorithm anemia arterial bleeding bruising clots disorders extravascular framework hemolysis hemolytic hemostasis
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
(DIC) Overview ... history of trauma, sepsis ... • Prolonged PT/PTT ... INR < 2.3 - APTT ... treatment #management #hematology
Causes of Prolonged PT (INR), Prolonged PTT • Prolonged PT (INR), Prolonged PTT • Prolonged PT
INR), Prolonged PTT ... (INR), Normal PTT ... #PPT #PT #INR #Differential ... Algorithm #Causes #Hematology ... #coagulation #disorders
ISTH Scoring System for Disseminated Intravascular Coagulation (DIC) Platelet count: • Expected: Low (or normal) • Elevation
Intravascular Coagulation ... (DIC) Platelet ... aggregation PT, aPTT ... small vessels #DIC ... Scoring #diagnosis #hematology
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Congenital intrinsic coagulation ... intravascular coagulation ... (DIC) c. ... Causes #diagnosis #differential ... #hematology #coagulation
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
Differential Diagnosis ... the PT and the aPTT ... intravascularcoagulation (DIC ... Causes #diagnosis #differential ... #hematology #coagulation
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Purpura - Differential ... Vasculopathy #Purpura #Differential ... #Diagnosis #hematology ... #rheumatology # ... #nonpalpable #dermatology
Causes of Leukocytosis and Leukopenia - Differential Diagnosis • Eosinophilia (AEC > 500, hypereosinophilia > 1500):
and Leukopenia - Differential ... • Eosinopenia: Sepsis ... Neoplastic • Neutropenia ... Benign ethnic neutropenia ... Diagnosis #causes #hematology
Causes of Arterial and Venous Thrombosis - Differential Diagnosis Framework STRUCTURAL: - PFO: paradoxical emboli - Popliteal
Venous Thrombosis - Differential ... intravascular coagulation ... (DIC) INFLAMMATORY ... MAHA: TTP, HUS, DIC ... Diagnosis #clots #hematology
Causes of Thrombocytopenia - Differential Diagnosis Framework Decreased Production: - Drugs (chemo, yang, sulfa, acetaminophen, NSAIDs, quinine,
Thrombocytopenia - Differential ... - Bacterial: Sepsis ... Microangiopathy: DIC ... Thrombocytopenia #Differential ... Diagnosis #Framework #hematology
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
of Hemostasis - Differential ... inhibitor of a coagulation ... Warfarin • Acute DIC ... disease • Acute DIC ... #Diagnosis #Hematology
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