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diagnosis algorithm causes blood oncology product reactions transaminitis abnormal aflp apml bilirubinemia chemistry classification coagulation comparison dic differentiation disseminated hellp
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Elevated Liver Enzymes ... - Differential ... Drugs • TPN • Sepsis ... • Others #LFTs ... #Hepatology #LiverEnzymes
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis Hepatocellular Pattern (ALT or AST > ALP):
Function Tests - Differential ... Drugs, Infection, Sepsis ... Burak @kwburak #LFTs ... #Elevated #Abnormal ... Algorithm #diagnosis #hepatology
Jaundice - Differential Diagnosis Algorithm Pre-Hepatic - Unconjugated Hyperbilirubinemia Increased Production • Hemolysis • Ineffective Erythropoiesis • Hematoma Decreased
Jaundice - Differential ... Production • Hemolysis ... Hepatic Uptake • Sepsis ... Post-Hepatic - Usually has ... Algorithm #Causes #Hepatology
Thrombocytopenia and Pregnancy - TTP/HUS, HELLP Syndrome and Acute Fatty Liver of Pregnancy (AFLP) Three syndromes in
Pregnancy - TTP/HUS ... defects. 1) HELLP (Hemolysis ... , Elevated Liver ... AFLP #obstetrics #hematology ... #diagnosis #table
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Interpretation of LFTs ... specificity to elevated ... chemistry #diagnosis #differential ... #Hepatology #transaminitis ... #LFTs #RValue #
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
fibrinogen • Elevated ... DDX: • TMA’s (HUS ... - MAHA: TTP/HUS ... causes #treatment #management ... #hematology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
if WBC > 5 or elevated ... initiation • Differential ... Diagnosis: Infection (sepsis ... APML #diagnosis #management ... #hematology #oncology
Blood Transfusion Reactions Immune Mediated: • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
• Febrile Non-Hemolytic ... Occurs between 0-6 hrs ... Can lead to sepsis ... Transfusion #diagnosis #management ... #hematology #reactions
Blood Product Transfusions One Pager Summary Type and screen - determines blood type and detects in recipient
Hemolysis on labs ... Occurs between 0-6 hrs ... Can lead to sepsis ... Transfusions #diagnosis #management ... #hematology #reactions
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
nodosum • Immune hemolytic ... Inflammatory marker elevated ... Immunohistochemical studies (to differentiate ... classification #hematology ... #oncology #management
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