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diagnosis hematology algorithm management causes anemia cardiology classification criticalcare hemolysis product bilirubinemia clinica clinical dermatology echocardiogram evaluation extravascular foamed hodgkins
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
uremic syndrome (HUS ... Other: Transfusion reaction ... - Transfusion reaction ... Extravascular #Causes #differential ... #diagnosis #hematology
Algorithm for workup of thrombocytopenia based on observation of the peripheral blood film. TTP/HUS indicates thrombotic
the peripheral blood ... TTP/HUS indicates ... thrombocytopenic purpura/hemolytic ... thrombocytopenia, Hematology ... #Diagnosis #Differential
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... - MAHA: TTP, HUS ... AIHA, Transfusion reactions ... - Peripheral Blood ... Diagnosis #hematology
Differential Diagnosis for Hemolytic Anemia Intrinsic Causes: • Enzyme deficiencies ex. G6PD, pyruvate kinase • Hemoglobinopathies
Differential Diagnosis ... for Hemolytic Anemia ... • MAHA: TTP, HUS ... • Transfusion reactions ... classification #hematology
Blood Transfusion Reactions Immune Mediated: • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
Blood Transfusion ... • Febrile Non-Hemolytic ... Occurs between 0-6 hrs ... Can lead to sepsis ... diagnosis #management #hematology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
Platelet Count - Differential ... hematologic: Acute blood ... loss, Acute hemolysis ... syndrome, POEMS • Reaction ... Exercise, Allergic reactions
Blood Product Transfusions One Pager Summary Type and screen - determines blood type and detects in recipient
- Acute Hemolytic ... Hemolysis on labs ... Occurs between 0-6 hrs ... Can lead to sepsis ... diagnosis #management #hematology
Jaundice - Differential Diagnosis Algorithm Pre-Hepatic - Unconjugated Hyperbilirubinemia Increased Production • Hemolysis • Ineffective Erythropoiesis • Hematoma Decreased
Jaundice - Differential ... Production • Hemolysis ... Hepatic Uptake • Sepsis ... Post-Hepatic - Usually has ... Algorithm #Causes #Hepatology
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Purpura - Differential ... disease - DIC/TTP/HUS ... - Hemolytic ... : • DIC, TTP/HUS ... fever • Drug reactions
Perhaps quite too often, the knee-jerk reaction to an elevated Troponin is to call our friends
the knee-jerk reaction ... increasing coronary blood ... are typically able ... Consider Sepsis, ... little coronary blood
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