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diagnosis causes liver pediatrics peds hematology hepatitis transaminitis blood product pulmonary reactions seizures treatment abnormal acute alcoholic alte apml brue
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI) DILI Types: • Intrinsic - predictable, dose dependent
Diagnosis and Management ... Chronic - ongoing ↑ LFTs ... Idiosyncratic #differential ... gastroenterology #algorithm ... gastroenterology #hepatology
Hepatocellular Liver Injury - Differential Diagnosis Framework: Liver Injury → liver test abnormalities without evidence of liver
- Differential ... : • Infections ... Diagnosis #hepatology ... #algorithm #Transaminitis ... #LFTs #hepatitis
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis Hepatocellular Pattern (ALT or AST > ALP):
Function Tests - Differential ... Diagnosis Algorithm ... Alcoholic Hep, Drugs, Infection ... Burak @kwburak #LFTs ... #diagnosis #hepatology
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Liver Enzymes - Differential ... Diagnosis Algorithm ... Drugs • TPN • Sepsis ... • Others #LFTs ... #Hepatology #LiverEnzymes
Patterns of Liver Injury Transaminase Levels: > 50x normal - Ischemic Hepatitis > 20x normal
Patterns of Liver Injury ... 10-20x normal - Infection ... Patterns #Liver #Injury ... #hepatology #LFTs ... transaminitis #differential
Causes of Acute Liver Injury - Differential Diagnosis Hepatocellular - Liver Parenchyma • Infectious: Hepatitis C, A,
of Acute Liver Injury ... - Differential ... : Sepsis, Viral ... Causes #Acute #algorithm ... #hepatology
Causes of Depressed / Lethargic Newborn - Differential Diagnosis Algorithm Maternal Related: • Drugs (Ex. SSRI) •
Lethargic Newborn - Differential ... Diagnosis Algorithm ... Congenital: • Birth Injury ... Malformation • TORCH Infection ... Aspiration • Sepsis
Causes of Apparent Life Threatening Event (ALTE) - Differential Diagnosis Algorithm Cardiac: • Congenital Heart Disease •
Event (ALTE) - Differential ... Diagnosis Algorithm ... Pneumonia • Sepsis ... Choking Spell Injury ... #Diagnosis #Algorithm
Causes of Sudden Unexpected Death in Infancy (SUDI) - Differential Diagnosis Algorithm Congenital Anomaly / Disorder: •
Infancy (SUDI) - Differential ... Diagnosis Algorithm ... Pneumonia • Sepsis ... Injury: • Deliberate ... #Diagnosis #Algorithm
Causes of Pleural Effusion - Differential Diagnosis Algorithm Transudate - Hydrostatic • Congestive heart failure • Constrictive
Pleural Effusion - Differential ... Diagnosis Algorithm ... Urinothorax Exudate - Infectious ... • Postcardiac injury ... #Hepatology #causes
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