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diagnosis differential product transfusion treatment alkaline alp anemia aplastic basophilia basophils coagulation comparison dic disseminated hemophagocytic hlh hyophosphatasia intravascular low
Basophilia - Differential Diagnosis Framework Basophils < 1% of the total white blood cell count Basophils function similarly
the total white blood ... during an allergic reaction ... Or Inflammatory Reactions ... : • Iron deficiency ... #hematology #basophils
TRALI vs TACO - Transfusion Reactions TRALI: • Epidemiology: 0.1% of transfused patientsl • Risk factors: Critical
- Transfusion Reactions ... of high parity blood ... donor • Pathophysiology ... without other cause ... #hematology #diagnosis
Blood Transfusion Reactions Immune Mediated: • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
recipients w/ IgA deficiency ... Causes purpura & ... TRALI): Leading cause ... Transfusion #diagnosis #management ... #hematology #reactions
Low Alkaline Phosphatase - Hypophosphatasia Is Low Alkaline Phosphatase Of Clinical Importance? ALP enzyme- Discovered in 1923 Low
• blood collection ... with EDTA Pathophysiology ... ) - Waddling gait ... Phosphatase: • Other causes ... Hyophosphatasia #hepatology
Blood Product Transfusions One Pager Summary Type and screen - determines blood type and detects in recipient
recipients w/ IgA deficiency ... Causes purpura & ... TRALI): Leading cause ... Transfusions #diagnosis #management ... #hematology #reactions
Causes of Neutropenia - Differential Diagnosis Neonate: - Infection - by far the most common cause -
Idiosyncratic drug reactions ... anemia-rare - Copper deficiency-rare ... Idiosyncratic drug reactions-most ... including white blood ... #hematology
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
ABO incompatible blood ... protein C and S Pathophysiology ... thrombopoietin deficiency ... #treatment #management ... #hematology
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Lymphohistiocytosis (HLH) Pathophysiology ... Phagocytosis of blood ... Cellular immune deficiency ... Lymphohistiocytosis #diagnosis #management ... treatment #summary #rheumatology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
and petechiae Causes ... , CTLA4 deficiency ... result from low blood ... Anemia #oncology #hematology ... #diagnosis #management
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