1019 results
Causes of Developmental Delay - Differential Diagnosis Algorithm
Isolated Domain Delay - Reduced Respiratory Drive:
 • Cognitive
- Differential Diagnosis ... Impairment: • Autism ... • Selective Mutism ... #Differential #Diagnosis
Pediatric Mood & Anxiety Disorders - Differential Diagnosis Algorithm
Bipolar
Mood
• Major Depressive Disorder
• Persistent Depressive Disorder
• Disruptive
- Differential Diagnosis ... Disorder • Selective Mutism ... #Differential #Diagnosis
Whipple Disease (Tropheryma whipplei) - Diagnosis and Management 

Caused by: Tropheryma whipplei

Symptoms and Signs:
1. Migratory poly/oligoarthralgia
Tropheryma whipplei) - Diagnosis ... and Management ... diarrhea (75%) Diagnostic ... • PAS-positive macrophages ... #algorithm #management
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
Macrophage Activation ... : Evidence of macrophage ... exchange #MAS #Macrophage ... Activation #Syndrome #Diagnosis ... #Management #Hematology
Leishmaniasis Life Cycle
1) Sandfly takes a blood meal (injects promastigote stage into the skin)
Human Stages:
2) Promastigotes
phagocytized by macrophages ... meal (ingests macrophages ... Leishmaniasis #LifeCycle #diagnosis
Gaucher Disease 

Pathophsiology
 • Lysosomal storage disorder
 • Deficiency of ß-glucocerebrosidase
• Accumulation of glucosylceramide in macrophages
Diagnosis
glucosylceramide in macrophages ... Diagnosis • ... Gauchers #Disease #Diagnosis
Visceral Leishmaniasis - Diagnosis and Management Summary
Species: Leishmania donovani, Leishmania infantum, Leishmania chagasi
Where: South Asia, East
Leishmaniasis - Diagnosis ... and Management ... replicate within macrophages ... Leishmaniasis #diagnosis ... #management #treatment
Invasive Candidiasis (IC)

Diagnosis:
Culture:
 • Gold standard, but Slow (~2-3 days), 50% sensitivity
 • Blood Sample
 •
Candidiasis (IC) Diagnosis ... Additional management ... IC #antifungal #diagnosis ... #management #candida ... #auris #treatment
Rare Invasive Yeasts - Species and Antifungal Therapy

Cryptococcus, 
Geotrichum, 
Kodamaea, 
(Pichia)ohmeri, 
Malassezia, 
Pseudozyma, 
Rhodotorula, 
Saccharomyces, 
Saprochaete
Trichosporon, Candida auris ... Antifungal #Therapy #Management
Hypersensitivity Types and Their Mechanisms
Type I - lgE - Soluble antigen
 - Allergen-specific lgE antibodies bind
killer cells, macrophages ... which activate macrophages ... Pathophysiology #Allergy #Diagnosis